LY305 ( LY 305;LY-305 )

Catalog No. M11820 CAS No. 1430230-83-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

LY305
Note

Research use only, not for human use.
Brief Description

LY305 (LY-305) is a non-steroidal selective androgen receptor modulator (SARM) with Ki of 2.03 nM.
Description

LY305 (LY-305) is a non-steroidal selective androgen receptor modulator (SARM) with Ki of 2.03 nM, demonstrates potent agonist activity in the aforementioned C2C12 cellular assay (EC50=0.499 nM); displays little to no affinity for GR, PR and MR (Ki>800 nM); shows the desired muscle and prostate effects in a preclinical ORX rat model.
Synonyms

LY 305;LY-305
Pathway

Endocrinology/Hormones
Target

Androgen Receptor (AR)
Recptor

Androgen Receptor (AR)
Research Area

——
Indication

——

CAS Number

1430230-83-3
Formula Weight

264.75
Molecular Formula

C14H17ClN2O
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

2-chloro-4-(((1R,2R)-2-hydroxy-2-methylcyclopentyl)amino)-3-methylbenzonitrile

1. Krishnan V, et al. Andrology. 2018 Mar 12. doi: 10.1111/andr.12479.
2. Saeed A, et al. J Med Chem. 2016 Jan 28;59(2):750-5.

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