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Home - Products - PI3K/Akt/mTOR signaling - GSK-3 - LY2090314

LY2090314

CAS No. 603288-22-8

LY2090314( LY2090314 | LY-2090314 | LY 2090314. )

Catalog No. M15255 CAS No. 603288-22-8

LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    LY2090314
  • Note
    Research use only, not for human use.
  • Brief Description
    LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM.
  • Description
    LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM; may improve the efficacy of platinum-based chemotherapy regimens. Phase 2.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    LY2090314 | LY-2090314 | LY 2090314.
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    GSK-3
  • Recptor
    GSK-3α| GSK-3β
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    603288-22-8
  • Formula Weight
    512.53
  • Molecular Formula
    C28H25FN6O3
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 2 mg/mL warmed (3.9 mM); DMSO: 100 mg/mL (195.11 mM)
  • SMILES
    O=C(C(C1=CN2C3=C1C=C(F)C=C3CN(C(N4CCCCC4)=O)CC2)=C5C6=CN=C7C=CC=CN76)NC5=O
  • Chemical Name
    3-(9-fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl)-4-(imidazo[1,2-a]pyridin-3-yl)-1H-pyrrole-2,5-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Brail LH, et al. J Clin Oncol, 2011, 29, abstr 3030.
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