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LV-320
CAS No. ——
LV-320( LV320 | LV 320 )
Catalog No. M16930 CAS No. ——
LV-320 (LV320) is a novel potent, cell-active, allosteric inhibitor of the autophagy-related cysteine protease ATG4B with IC50 of 24.5 uM in ATG4B cleavage assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameLV-320
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NoteResearch use only, not for human use.
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Brief DescriptionLV-320 (LV320) is a novel potent, cell-active, allosteric inhibitor of the autophagy-related cysteine protease ATG4B with IC50 of 24.5 uM in ATG4B cleavage assays.
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DescriptionLV-320 (LV320) is a novel potent, cell-active, allosteric inhibitor of the autophagy-related cysteine protease ATG4B with IC50 of 24.5 uM in ATG4B cleavage assays; LV-320 binds to ATG4B and is an uncompetitive inhibitor of ATG4B with Kd of 16 uM; blocks starvation-induced autophagic fux in vitro; also inhibit ATG4A with an IC50 of 35.5 uM, but does not shows meaningful inhibition for caspase-3 or cathepsin B; LV-320 reduces autophagic fux in vitro and is bioavailable and active in vivo, LV-320 is a relevant chemical tool to study the various roles of ATG4B in cancer and other contexts.
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In Vitro——
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In Vivo——
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SynonymsLV320 | LV 320
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PathwayAutophagy
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TargetAtg
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RecptorAtg
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight520.102
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Molecular FormulaC29H26ClNO2S2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(O)CCSC(C1=CC=C(/C=C/C2=CC=NC3=CC(Cl)=CC=C23)C=C1)SCCC4=CC=CC=C4
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Chemical Name(E)-3-(((4-(2-(7-chloroquinolin-4-yl)vinyl)phenyl)(phenethylthio)methyl)thio)propanoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bosc D, et al. Sci Rep. 2018 Aug 3;8(1):11653. doi: 10.1038/s41598-018-29900-x.
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