I-BRD9 ( I-BRD9; I-BRD-9; I-BRD 9 )

Catalog No. M12612 CAS No. 1714146-59-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

I-BRD9
Note

Research use only, not for human use.
Brief Description

The first selective cellular chemical probe for BRD9 with pIC50 of 7.3.
Description

The first selective cellular chemical probe for BRD9 with pIC50 of 7.3; displays 700-fold selectivity over the BET family and 200-fold over the highly homologous BRD7; decreases cell proliferation, G1-arrest and apoptosis in rhabdoid tumor cells; shows synergistic inhibitory effects on cell proliferation combined with doxorubicin or carboplatin.
Synonyms

I-BRD9; I-BRD-9; I-BRD 9
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

BRD4;BRD9
Research Area

Other Indications
Indication

——

CAS Number

1714146-59-4
Formula Weight

497.55
Molecular Formula

C22H22F3N3O3S2
Purity

>98% (HPLC)
Solubility

DMSO: 15.5 mg/mL
SMILES

N=C(C(S1)=CC2=C1C(C3=CC=CC(C(F)(F)F)=C3)=CN(CC)C2=O)NC(CC4)CCS4(=O)=O
Chemical Name

Thieno[3,2-c]pyridine-2-carboximidamide, 5-ethyl-4,5-dihydro-4-oxo-N-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-7-[3-(trifluoromethyl)phenyl]-

1. Theodoulou NH, et al. J Med Chem. 2016 Feb 25;59(4):1425-39.
2. Krmer KF, et al. Int J Mol Sci. 2017 Jul 16;18(7). pii: E1537.

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