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LOC14

CAS No. 877963-94-5

LOC14( —— )

Catalog No. M20192 CAS No. 877963-94-5

LOC14 to be the most potent PDI inhibitor reported to date( EC50 : 500 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    LOC14
  • Note
    Research use only, not for human use.
  • Brief Description
    LOC14 to be the most potent PDI inhibitor reported to date( EC50 : 500 nM).
  • Description
    LOC14 to be the most potent PDI inhibitor reported to date( EC50 : 500 nM).
  • In Vitro
    Cell Viability Assay Cell Line:MTEC cells Concentration:0.01 μM; 0.1 μM; 0.5 μM; 1 μM; 5 μM; 10 μM; 100 μM Incubation Time:24 hours Result:Inhibited recombinant (r)PDIA3 activity.
  • In Vivo
    Animal Model:Male N171–82Q HD mice Dosage:20 mg/kg Administration:Orally administered by gavage; 20 mg/kg; once daily; 12-28 weeks Result:Improved motor function in HD mice.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PDI
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    877963-94-5
  • Formula Weight
    317.4
  • Molecular Formula
    C16H19N3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:25 mg/mL?(78.76 mM)
  • SMILES
    O=C(C1CC1)N1CCN(Cn2sc3ccccc3c2=O)CC1
  • Chemical Name
    2-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]methyl]-12-benzisothiazol-3(2H)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kaplan A et al. Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):E2245-52.
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