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LMD-A

CAS No. 850330-77-7

LMD-A( CCR8 antagonist LMD-A )

Catalog No. M16174 CAS No. 850330-77-7

LMD-A (CCR8 antagonist LMD-A) is a highly potent, small molecule antagonist of chemokine receptor CCR8 with EC50 of 2.5 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    LMD-A
  • Note
    Research use only, not for human use.
  • Brief Description
    LMD-A (CCR8 antagonist LMD-A) is a highly potent, small molecule antagonist of chemokine receptor CCR8 with EC50 of 2.5 nM.
  • Description
    LMD-A (CCR8 antagonist LMD-A) is a highly potent, small molecule antagonist of chemokine receptor CCR8 with EC50 of 2.5 nM; inhibits 10 nM CCL1-induced activation of CCR8 with EC50 of 12 nM, inhibits 4DE4 cells cell migration induced by 3 nM CCL1 with EC50 of 0.58 nM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    CCR8 antagonist LMD-A
  • Pathway
    GPCR/G Protein
  • Target
    Chemokine Receptor
  • Recptor
    Chemokine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    850330-77-7
  • Formula Weight
    508.637
  • Molecular Formula
    C27H32N4O4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(NC1=C2C=CC=C(S(=O)(N[C@H]3[C@H](C)CN(C([C@H](C)N)=O)CC3)=O)C2=CC=C1)C4=CC=CC=C4C
  • Chemical Name
    N-(5-(N-((3R,4R)-1-(L-alanyl)-3-methylpiperidin-4-yl)sulfamoyl)naphthalen-1-yl)-2-methylbenzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rummel PC, et al. Br J Pharmacol. 2012 Nov;167(6):1206-17. 2. Barington L, et al. J Biol Chem. 2016 Jul 29;291(31):16208-20.
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