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GSK812397
CAS No. 878197-98-9
GSK812397( GSK 812397 | GSK-812397 )
Catalog No. M16375 CAS No. 878197-98-9
GSK812397 is a potent, selective, noncompetitive, orally available antagonist of CXCR4 receptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameGSK812397
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NoteResearch use only, not for human use.
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Brief DescriptionGSK812397 is a potent, selective, noncompetitive, orally available antagonist of CXCR4 receptor.
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DescriptionGSK812397 is a potent, selective, noncompetitive, orally available antagonist of CXCR4 receptor, inhibits entry of X4-tropic strains of HIV-1 with IC50 of 4.60 nM and 1.50 nM in PBMCs and HOS assays, respectively; does not block CCR5-mediated viral entry in the R5 viral HOS assay (IC50>25 uM); produces a concentration-dependent decrease in both an SDF-1-mediated chemotaxis and intracellular calcium release (IC50=0.34 nM and 2.41 nM, respectively) in cell-based functional assays; demonstrates antiviral activity against a broad range of X4-utilizing strains of HIV-1.
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In Vitro——
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In Vivo——
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SynonymsGSK 812397 | GSK-812397
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PathwayGPCR/G Protein
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TargetChemokine Receptor
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RecptorChemokine Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number878197-98-9
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Formula Weight420.561
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Molecular FormulaC24H32N6O
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Purity>98% (HPLC)
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Solubility——
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SMILESOCC1=C(CN([C@@H]2C3=C(C=CC=N3)CCC2)C)N=C4C=CC=C(N5CCN(C)CC5)N41
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Chemical Name(S)-(2-((methyl(5,6,7,8-tetrahydroquinolin-8-yl)amino)methyl)-5-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyridin-3-yl)methanol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jenkinson S, et al. Antimicrob Agents Chemother. 2010 Feb;54(2):817-24.
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