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LM11A-31
CAS No. 102562-74-3
LM11A-31( LM11A 31 )
Catalog No. M10118 CAS No. 102562-74-3
An orally available, brain penetrant p75NTR ligand that blocks p75-mediated cell death, also increases proliferation and survival of hippocampal neural progenitors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 100MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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Biological Information
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Product NameLM11A-31
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NoteResearch use only, not for human use.
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Brief DescriptionAn orally available, brain penetrant p75NTR ligand that blocks p75-mediated cell death, also increases proliferation and survival of hippocampal neural progenitors.
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DescriptionAn orally available, brain penetrant p75NTR ligand that blocks p75-mediated cell death, also increases proliferation and survival of hippocampal neural progenitors; shows no effect on nerve growth factor (NGF) binding to TrkA; prevents and reverses atrophy of cholinergic neurites, as well as reversing AD pathologies in mid- to late-stage AD mice models.Alzheimer Disease Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsLM11A 31
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PathwayTyrosine Kinase
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TargetTrk Receptor
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RecptorTrk Receptor
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Research AreaNeurological Disease
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IndicationAlzheimer Disease
Chemical Information
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CAS Number102562-74-3
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Formula Weight243.351
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Molecular FormulaC12H25N3O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(2S,3S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Massa SM, et al. J Neurosci. 2006 May 17;26(20):5288-300.
2. Meeker RB, et al. J Neuroimmune Pharmacol. 2012 Jun;7(2):388-400.
3. Simmons DA, et al. PLoS One. 2014 Aug 25;9(8):e102136.
4. Meeker RB, et al. Exp Neurol. 2016 Jan;275 Pt 1:182-98.
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