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AZ-23
CAS No. 915720-21-7
AZ-23( AZ23 | AZ 23 )
Catalog No. M24963 CAS No. 915720-21-7
AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 194 | In Stock |
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| 25MG | 419 | In Stock |
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| 50MG | 717 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAZ-23
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NoteResearch use only, not for human use.
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Brief DescriptionAZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C.
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DescriptionAZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2 nM, 8 nM, 24 nM, 52 nM, 55 nM, 84 nM, 99 nM, respectively.
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In VitroAZ-23 potently and selectivity inhibits Trk phosphorylation in cells. AZ-23 potently inhibits Trk-mediated survival (EC50 of 2 nM). AZ-23 Inhibits Trk-Dependent Survival in MCF10ATrkA-Δ and TF-1 Cell Lines.
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In VivoAZ-23 shows in vivo TrkA kinase inhibition and efficacy in mice following oral administration in a TrkA-driven allograft model and significant tumor growth inhibition in a Trk-expressing xenograft model of neuroblastoma.
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SynonymsAZ23 | AZ 23
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PathwayTyrosine Kinase
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TargetTrk Receptor
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RecptorTrkA|TrkB
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Research Area——
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Indication——
Chemical Information
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CAS Number915720-21-7
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Formula Weight391.83
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Molecular FormulaC17H19ClFN7O
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Purity>98% (HPLC)
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SolubilityDMSO:125 mg/mL (319.02 mM; Need ultrasonic)
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SMILESCC(C)Oc1n[nH]c(Nc(nc(N[C@@H](C)c(cc2)ncc2F)nc2)c2Cl)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Thress K, et al. Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway. Mol Cancer Ther. 2009 Jul; 8(7):1818-27.
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