Cart
sales@molnova.com
LDN-57444
CAS No. 668467-91-2
LDN-57444 ( Ubiquitin C-terminal Hydrolase L1 Inhibitor; UCH-L1 Inhibitor )
Catalog No. M15554 CAS No. 668467-91-2
A reversible, competitive, active site-directed Uch-L1 inhibitor with IC50 of 0.88 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 31 | In Stock |
|
| 5MG | 46 | In Stock |
|
| 10MG | 83 | In Stock |
|
| 25MG | 158 | In Stock |
|
| 50MG | 282 | In Stock |
|
| 100MG | 437 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameLDN-57444
-
NoteResearch use only, not for human use.
-
Brief DescriptionA reversible, competitive, active site-directed Uch-L1 inhibitor with IC50 of 0.88 uM.
-
DescriptionA reversible, competitive, active site-directed Uch-L1 inhibitor with IC50 of 0.88 uM; shows weak inhibition on Uch-L3 (IC50> 20 uM); causes cell death through the apoptosis pathway by decreasing the activity of ubiquitin proteasome system and increasing the levels of highly ubiquitinated proteins, both of which can activate UPR.
-
SynonymsUbiquitin C-terminal Hydrolase L1 Inhibitor; UCH-L1 Inhibitor
-
PathwayProteasome/Ubiquitin
-
TargetDUB
-
RecptorUCH-L1;UCH-L3
-
Research AreaNeurological Disease
-
Indication——
Chemical Information
-
CAS Number668467-91-2
-
Formula Weight397.64
-
Molecular FormulaC17H11Cl3N2O3
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESO=C1N(CC2=CC(Cl)=CC=C2Cl)C3=C(C=C(Cl)C=C3)/C1=N/OC(C)=O
-
Chemical Name1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime)
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Gong B, et al. Cell. 2006 Aug 25;126(4):775-88.
2. Xie M, et al. J Alzheimers Dis. 2016;49(2):353-63.
3. Tan YY, et al. Mol Cell Biochem. 2008 Nov;318(1-2):109-15.
2. Xie M, et al. J Alzheimers Dis. 2016;49(2):353-63.
3. Tan YY, et al. Mol Cell Biochem. 2008 Nov;318(1-2):109-15.
molnova catalog
related products
-
IU-1
IU-1 (USP14 inhibitor IU1) is a specific, small molecule inhibitor of deubiquitinating enzyme USP14 with IC50 of 4-5 uM.
-
PR-619
PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay.
-
GNE-6776
GNE-6776 is a novel potent, specific, non-covalent, orally bioavailable USP7 inhibitor with IC50 of 1.34 uM.
