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LDN-57444
CAS No. 668467-91-2
LDN-57444 ( Ubiquitin C-terminal Hydrolase L1 Inhibitor; UCH-L1 Inhibitor )
Catalog No. M15554 CAS No. 668467-91-2
A reversible, competitive, active site-directed Uch-L1 inhibitor with IC50 of 0.88 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 31 | In Stock |
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| 5MG | 46 | In Stock |
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| 10MG | 83 | In Stock |
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| 25MG | 158 | In Stock |
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| 50MG | 282 | In Stock |
|
| 100MG | 437 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLDN-57444
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NoteResearch use only, not for human use.
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Brief DescriptionA reversible, competitive, active site-directed Uch-L1 inhibitor with IC50 of 0.88 uM.
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DescriptionA reversible, competitive, active site-directed Uch-L1 inhibitor with IC50 of 0.88 uM; shows weak inhibition on Uch-L3 (IC50> 20 uM); causes cell death through the apoptosis pathway by decreasing the activity of ubiquitin proteasome system and increasing the levels of highly ubiquitinated proteins, both of which can activate UPR.
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SynonymsUbiquitin C-terminal Hydrolase L1 Inhibitor; UCH-L1 Inhibitor
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PathwayProteasome/Ubiquitin
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TargetDUB
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RecptorUCH-L1;UCH-L3
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number668467-91-2
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Formula Weight397.64
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Molecular FormulaC17H11Cl3N2O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C1N(CC2=CC(Cl)=CC=C2Cl)C3=C(C=C(Cl)C=C3)/C1=N/OC(C)=O
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Chemical Name1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gong B, et al. Cell. 2006 Aug 25;126(4):775-88.
2. Xie M, et al. J Alzheimers Dis. 2016;49(2):353-63.
3. Tan YY, et al. Mol Cell Biochem. 2008 Nov;318(1-2):109-15.
2. Xie M, et al. J Alzheimers Dis. 2016;49(2):353-63.
3. Tan YY, et al. Mol Cell Biochem. 2008 Nov;318(1-2):109-15.
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