LDN-212320
CAS No. 894002-50-7
LDN-212320 ( LDN/OSU-0212320; LDN-0212320; OSU-0212320 )
Catalog No. M26737 CAS No. 894002-50-7
LDN-212320 is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by > 6 fold at concentrations < 5 μM after 24 h.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 35 | Get Quote |
|
5MG | 58 | Get Quote |
|
10MG | 88 | Get Quote |
|
25MG | 178 | Get Quote |
|
50MG | 336 | Get Quote |
|
100MG | 504 | Get Quote |
|
500MG | 1071 | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameLDN-212320
-
NoteResearch use only, not for human use.
-
Brief DescriptionLDN-212320 is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by > 6 fold at concentrations < 5 μM after 24 h.
-
DescriptionLDN-212320 is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by > 6 fold at concentrations < 5 μM after 24 h.(In Vitro):LDN/OSU-0212320 enhanced EAAT2 protein levels and glutamate uptake function but did not affect EAAT1 or EAAT3 protein levels and it also increased EAAT2 protein levels in a dose-dependent (EC50: 1.83 ± 0.27 μM) and time-dependent manner. LDN/OSU-0212320 treatment markedly prevented neuronal loss and degeneration, as assessed by MAP2 immunostaining .(In Vivo):After LDN/OSU-0212320(a single i.p.; 40-mg/kg) treatment, EAAT2 protein levels and associated glutamate uptake increased by approximately 1.5- to 2-fold at 2 hours and by approximately 2- to 3-fold between 8 and 24 hours after injection. Even 72 hours after injection, an approximately 1.5-fold increase in EAAT2 protein levels could still be detected (data not shown). LDN/OSU-0212320–induced EAAT2 protein levels and glutamate uptake was dose-dependent .
-
SynonymsLDN/OSU-0212320; LDN-0212320; OSU-0212320
-
PathwayOthers
-
TargetOther Targets
-
RecptorNK2
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number894002-50-7
-
Formula Weight293.4
-
Molecular FormulaC17H15N3S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCc1ccccc1CSc1ccc(nn1)-c1ccccn1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Pluck G. Preliminary Validation of a Free-to-Use, Brief Assessment of Adult Intelligence for Research Purposes: The Matrix Matching Test. Psychol Rep. 2018 Jan 1:33294118762589.
molnova catalog
related products
-
Dantrolene
Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.
-
2-Methylglutaric aci...
2-Methylglutaric acid is an organic acid normally found in human urine in healthy adults and children. 2-Methylglutaric acid is a metabolite of succinic acid a citric acid cycle intermediate.
-
(R)-Reticuline
(R)-Reticuline is the biosynthetic precursor of the morphinan alkaloids.