LDN-212320
CAS No. 894002-50-7
LDN-212320 ( LDN/OSU-0212320; LDN-0212320; OSU-0212320 )
Catalog No. M26737 CAS No. 894002-50-7
LDN-212320 is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by > 6 fold at concentrations < 5 μM after 24 h.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 35 | Get Quote |
|
5MG | 58 | Get Quote |
|
10MG | 88 | Get Quote |
|
25MG | 178 | Get Quote |
|
50MG | 336 | Get Quote |
|
100MG | 504 | Get Quote |
|
500MG | 1071 | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameLDN-212320
-
NoteResearch use only, not for human use.
-
Brief DescriptionLDN-212320 is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by > 6 fold at concentrations < 5 μM after 24 h.
-
DescriptionLDN-212320 is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by > 6 fold at concentrations < 5 μM after 24 h.(In Vitro):LDN/OSU-0212320 enhanced EAAT2 protein levels and glutamate uptake function but did not affect EAAT1 or EAAT3 protein levels and it also increased EAAT2 protein levels in a dose-dependent (EC50: 1.83 ± 0.27 μM) and time-dependent manner. LDN/OSU-0212320 treatment markedly prevented neuronal loss and degeneration, as assessed by MAP2 immunostaining .(In Vivo):After LDN/OSU-0212320(a single i.p.; 40-mg/kg) treatment, EAAT2 protein levels and associated glutamate uptake increased by approximately 1.5- to 2-fold at 2 hours and by approximately 2- to 3-fold between 8 and 24 hours after injection. Even 72 hours after injection, an approximately 1.5-fold increase in EAAT2 protein levels could still be detected (data not shown). LDN/OSU-0212320–induced EAAT2 protein levels and glutamate uptake was dose-dependent .
-
SynonymsLDN/OSU-0212320; LDN-0212320; OSU-0212320
-
PathwayOthers
-
TargetOther Targets
-
RecptorNK2
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number894002-50-7
-
Formula Weight293.4
-
Molecular FormulaC17H15N3S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCc1ccccc1CSc1ccc(nn1)-c1ccccn1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Pluck G. Preliminary Validation of a Free-to-Use, Brief Assessment of Adult Intelligence for Research Purposes: The Matrix Matching Test. Psychol Rep. 2018 Jan 1:33294118762589.
molnova catalog
related products
-
ELA-32 (human)
Potent, high affinity apelin receptor agonist (IC50 = 0.27 nM; Kd = 0.51 nM). Exhibits no binding GPR15 and GPR25. Activates the PI3K/AKT pathway and promotes self-renewal of hESCs via cell-cycle progression and protein translation. Also potentiates the TGFβ pathway, priming hESCs toward the endoderm lineage. Stimulates angiogenesis in HUVEC cells. Relaxes mouse aortic vessels. Functions as an anorexigenic hormone through activation of the AVP and CRH neurons in the PVN.
-
Glucobrassicanapin
The seeds of Lepidium apetalum.
-
Angelicide
Angelicide is a natural product.