LDN-212320

CAS No. 894002-50-7

LDN-212320 ( LDN/OSU-0212320; LDN-0212320; OSU-0212320 )

Catalog No. M26737 CAS No. 894002-50-7

LDN-212320 is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by > 6 fold at concentrations < 5 μM after 24 h.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 35 Get Quote
5MG 58 Get Quote
10MG 88 Get Quote
25MG 178 Get Quote
50MG 336 Get Quote
100MG 504 Get Quote
500MG 1071 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    LDN-212320
  • Note
    Research use only, not for human use.
  • Brief Description
    LDN-212320 is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by > 6 fold at concentrations < 5 μM after 24 h.
  • Description
    LDN-212320 is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by > 6 fold at concentrations < 5 μM after 24 h.(In Vitro):LDN/OSU-0212320 enhanced EAAT2 protein levels and glutamate uptake function but did not affect EAAT1 or EAAT3 protein levels and it also increased EAAT2 protein levels in a dose-dependent (EC50: 1.83 ± 0.27 μM) and time-dependent manner. LDN/OSU-0212320 treatment markedly prevented neuronal loss and degeneration, as assessed by MAP2 immunostaining .(In Vivo):After LDN/OSU-0212320(a single i.p.; 40-mg/kg) treatment, EAAT2 protein levels and associated glutamate uptake increased by approximately 1.5- to 2-fold at 2 hours and by approximately 2- to 3-fold between 8 and 24 hours after injection. Even 72 hours after injection, an approximately 1.5-fold increase in EAAT2 protein levels could still be detected (data not shown). LDN/OSU-0212320–induced EAAT2 protein levels and glutamate uptake was dose-dependent .
  • Synonyms
    LDN/OSU-0212320; LDN-0212320; OSU-0212320
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    NK2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    894002-50-7
  • Formula Weight
    293.4
  • Molecular Formula
    C17H15N3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cc1ccccc1CSc1ccc(nn1)-c1ccccn1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Pluck G. Preliminary Validation of a Free-to-Use, Brief Assessment of Adult Intelligence for Research Purposes: The Matrix Matching Test. Psychol Rep. 2018 Jan 1:33294118762589.
molnova catalog
related products
  • Dantrolene

    Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.

  • 2-Methylglutaric aci...

    2-Methylglutaric acid is an organic acid normally found in human urine in healthy adults and children. 2-Methylglutaric acid is a metabolite of succinic acid a citric acid cycle intermediate.

  • (R)-Reticuline

    (R)-Reticuline is the biosynthetic precursor of the morphinan alkaloids.