LDN-212320
CAS No. 894002-50-7
LDN-212320 ( LDN/OSU-0212320; LDN-0212320; OSU-0212320 )
Catalog No. M26737 CAS No. 894002-50-7
LDN-212320 is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by > 6 fold at concentrations < 5 μM after 24 h.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 35 | Get Quote |
|
5MG | 58 | Get Quote |
|
10MG | 88 | Get Quote |
|
25MG | 178 | Get Quote |
|
50MG | 336 | Get Quote |
|
100MG | 504 | Get Quote |
|
500MG | 1071 | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameLDN-212320
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NoteResearch use only, not for human use.
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Brief DescriptionLDN-212320 is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by > 6 fold at concentrations < 5 μM after 24 h.
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DescriptionLDN-212320 is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by > 6 fold at concentrations < 5 μM after 24 h.(In Vitro):LDN/OSU-0212320 enhanced EAAT2 protein levels and glutamate uptake function but did not affect EAAT1 or EAAT3 protein levels and it also increased EAAT2 protein levels in a dose-dependent (EC50: 1.83 ± 0.27 μM) and time-dependent manner. LDN/OSU-0212320 treatment markedly prevented neuronal loss and degeneration, as assessed by MAP2 immunostaining .(In Vivo):After LDN/OSU-0212320(a single i.p.; 40-mg/kg) treatment, EAAT2 protein levels and associated glutamate uptake increased by approximately 1.5- to 2-fold at 2 hours and by approximately 2- to 3-fold between 8 and 24 hours after injection. Even 72 hours after injection, an approximately 1.5-fold increase in EAAT2 protein levels could still be detected (data not shown). LDN/OSU-0212320–induced EAAT2 protein levels and glutamate uptake was dose-dependent .
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SynonymsLDN/OSU-0212320; LDN-0212320; OSU-0212320
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PathwayOthers
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TargetOther Targets
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RecptorNK2
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Research Area——
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Indication——
Chemical Information
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CAS Number894002-50-7
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Formula Weight293.4
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Molecular FormulaC17H15N3S
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Purity>98% (HPLC)
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Solubility——
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SMILESCc1ccccc1CSc1ccc(nn1)-c1ccccn1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Pluck G. Preliminary Validation of a Free-to-Use, Brief Assessment of Adult Intelligence for Research Purposes: The Matrix Matching Test. Psychol Rep. 2018 Jan 1:33294118762589.
molnova catalog
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