T3Inh-1

CAS No. 50440-30-7

T3Inh-1 ( —— )

Catalog No. M28859 CAS No. 50440-30-7

T3Inh-1 is an effective and selective inhibitor of ppGalNAc-T3 with an IC50 of 7 μM. T3Inh-1 prevents breast cancer cells. T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 260 Get Quote
10MG 430 Get Quote
25MG 710 Get Quote
50MG 972 Get Quote
100MG 1332 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    T3Inh-1
  • Note
    Research use only, not for human use.
  • Brief Description
    T3Inh-1 is an effective and selective inhibitor of ppGalNAc-T3 with an IC50 of 7 μM. T3Inh-1 prevents breast cancer cells. T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects.
  • Description
    T3Inh-1 is an effective and selective inhibitor of ppGalNAc-T3 with an IC50 of 7 μM. T3Inh-1 prevents breast cancer cells. T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects. (In Vitro):In HEK cells, T3Inh-1 (6h)increased the cleavage of FGF23. In MDA-MB231 cells, T3Inh-1(5 μM; 24h, 48h) inhibited migration by >80% and invasion by 98% while causing no discernable effect on cell proliferation. T3Inh-1 exhibited no toxicity and did not affect HEK cell proliferation.(In Vivo):In Wild-type C57BL/6 mice, T3Inh-1 (25, 50 mg/kg; i.p.) blocked ppGalNAc-T3-mediated glycan-masking of FGF23 and increased its cleavage.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    5-HT3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    50440-30-7
  • Formula Weight
    476.5
  • Molecular Formula
    C27H20N6O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    [O-][N+](c(ccc1ncc2)cc1c2Nc(cc1)ccc1C(Nc(cc1)ccc1Nc1ccncc1)=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.van Wijngaarden I, et al. Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives. J Med Chem. 1993 Nov 12;36(23):3693-9.
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