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T3Inh-1
CAS No. 50440-30-7
T3Inh-1 ( —— )
Catalog No. M28859 CAS No. 50440-30-7
T3Inh-1 is an effective and selective inhibitor of ppGalNAc-T3 with an IC50 of 7 μM. T3Inh-1 prevents breast cancer cells. T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 260 | Get Quote |
|
| 10MG | 430 | Get Quote |
|
| 25MG | 710 | Get Quote |
|
| 50MG | 972 | Get Quote |
|
| 100MG | 1332 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameT3Inh-1
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NoteResearch use only, not for human use.
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Brief DescriptionT3Inh-1 is an effective and selective inhibitor of ppGalNAc-T3 with an IC50 of 7 μM. T3Inh-1 prevents breast cancer cells. T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects.
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DescriptionT3Inh-1 is an effective and selective inhibitor of ppGalNAc-T3 with an IC50 of 7 μM. T3Inh-1 prevents breast cancer cells. T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects. (In Vitro):In HEK cells, T3Inh-1 (6h)increased the cleavage of FGF23. In MDA-MB231 cells, T3Inh-1(5 μM; 24h, 48h) inhibited migration by >80% and invasion by 98% while causing no discernable effect on cell proliferation. T3Inh-1 exhibited no toxicity and did not affect HEK cell proliferation.(In Vivo):In Wild-type C57BL/6 mice, T3Inh-1 (25, 50 mg/kg; i.p.) blocked ppGalNAc-T3-mediated glycan-masking of FGF23 and increased its cleavage.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor5-HT3
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Research Area——
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Indication——
Chemical Information
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CAS Number50440-30-7
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Formula Weight476.5
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Molecular FormulaC27H20N6O3
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Purity>98% (HPLC)
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Solubility——
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SMILES[O-][N+](c(ccc1ncc2)cc1c2Nc(cc1)ccc1C(Nc(cc1)ccc1Nc1ccncc1)=O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.van Wijngaarden I, et al. Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives. J Med Chem. 1993 Nov 12;36(23):3693-9.
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