LC-1028 ( LC1028;LC 1028 )

Catalog No. M13662 CAS No. 2324158-08-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

LC-1028
Note

Research use only, not for human use.
Brief Description

LC-1028 (LC1028) is a novel potent selective, covalent and irreversible inhibitor of p97 (valosin-containing protein).
Description

LC-1028 (LC1028) is a novel potent selective, covalent and irreversible inhibitor of p97 (valosin-containing protein), remains essentially irreversible ac tivity against p97 mutant C522A.
Synonyms

LC1028;LC 1028
Pathway

Proteasome/Ubiquitin
Target

p97
Recptor

p97
Research Area

——
Indication

——

CAS Number

2324158-08-7
Formula Weight

449.56
Molecular Formula

C28H27N5O
Purity

>98% (HPLC)
Solubility

——
SMILES

CC#CC(NC1=CC=CC2=C1C=C(C)N2C3=NC(NCC4=CC=CC=C4)=C5CCCCC5=N3)=O
Chemical Name

N-(1-(4-(Benzylamino)-5,6,7,8-tetrahydroquinazolin-2-yl)-2-methyl-1H-indol-4-yl)but-2-ynamide

1. Ding R, et al. J Med Chem. 2019 Mar 14;62(5):2814-2829.

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