L48H37

CAS No. 343307-76-6

L48H37 ( —— )

Catalog No. M28299 CAS No. 343307-76-6

L48H37 is an analog of Curcumin (HY-N0005) with improved chemical stability. L48H37 is a potent and specific myeloid differentiation protein 2 (MD2) inhibitor and inhibits the interaction and signaling transduction of LPS-TLR4/MD2.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 35 Get Quote
5MG 58 Get Quote
10MG 87 Get Quote
25MG 177 Get Quote
50MG 282 Get Quote
100MG 462 Get Quote
500MG 981 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    L48H37
  • Note
    Research use only, not for human use.
  • Brief Description
    L48H37 is an analog of Curcumin (HY-N0005) with improved chemical stability. L48H37 is a potent and specific myeloid differentiation protein 2 (MD2) inhibitor and inhibits the interaction and signaling transduction of LPS-TLR4/MD2.
  • Description
    L48H37 is an analog of Curcumin (HY-N0005) with improved chemical stability. L48H37 is a potent and specific myeloid differentiation protein 2 (MD2) inhibitor and inhibits the interaction and signaling transduction of LPS-TLR4/MD2. (In Vitro):L48H37 inhibits LPS-induced inflammation, particularly TNF-α and IL-6 production and gene expression in mouse macrophages .L48H37 (0-20 μM; 24 hours) decreases the viability of A549 and H460 cells with IC 50 values of 5.3 μM and 2.3 μM, respectively, which is more effective compared to curcumin in lung cancer cells. It shows a low cytotoxicity on normal human lung epithelial cells (BEAS-2B) with IC 50 of 21 μM .L48H37 (1, 2, or 4 μM; 16 hours) dose‐dependently inhibited the expression of p‐Cdc2 and Cdc2, and increases the expression of p53. It also shows increased levels of cleaved poly (ADP‐ribosyl) polymerase (PARP) and reduced levels of anti‐apoptotic protein Bcl‐2 in H460 and A549 cells .L48H37 (4 μM; 16 hours) rapidly induces intracellular ROS levels dose-dependently as detected by increased DCF levels in H460 and A549 cells . Cell Viability Assay Cell Line: A549 and H460 cells; BEAS-2B cells Concentration: 0.625, 1.25, 2.5, 5, 7.5, 10, and 20μM Incubation Time: 24 hours Result: Inhibited lung cancer cells growth in a concentration-dependent manner. Western Blot Analysis Cell Line: A549 and H460 cells Concentration: 0.625, 1.25, 2.5, 5, 7.5, 10, and 20μM Incubation Time: 24 hours Result: Decreased p‐Cdc2, Cdc2, and Bcl‐2 expression in 2 lung cancer cells.(In Vivo):L48H37 (intraperitoneal injection; 5 mg or 10 mg/kg; once daily; 11‐day) inhibits H460 xenograft tumor growth and exhibits anti‐tumor activity in mice . Animal Model: 5‐week‐old athymic BALB/cA nu/nu female mice (18‐22 g) Dosage: 5 mg or 10 mg/kg Administration: Intraperitoneal injection; once daily; 11‐day Result: Reduced tumor wet weights as compared to vehicle control.Decreased the levels of p‐STAT3, and increased the levels of p‐EIF2α and ATF4 in vivo.Exhibited no significant structural changes in mice.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    NO Synthase;TNF-α;NOS;inflammation;CCL4;Antioxidant
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    343307-76-6
  • Formula Weight
    483.6
  • Molecular Formula
    C27H33NO7
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCN1CC(=CC2=CC(OC)=C(OC)C(OC)=C2)C(=O)C(C1)=CC1=CC(OC)=C(OC)C(OC)=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lin CH, et al. Eburicoic Acid, a Triterpenoid Compound from Antrodia camphorata, Displays Antidiabetic and Antihyperlipidemic Effects in Palmitate-Treated C2C12 Myotubes and in High-Fat Diet-Fed Mice.?Int J Mol Sci. 2017;18(11):2314. Published 2017 Nov 2.
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