L-Homopropargylglycine( —— )

Catalog No. M33399 CAS No. 98891-36-2

L-Homopropargylglycine is an alkyl chain-based PROTAC linker utilized in the synthesis of PROTACs.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

L-Homopropargylglycine
Note

Research use only, not for human use.
Brief Description

L-Homopropargylglycine is an alkyl chain-based PROTAC linker utilized in the synthesis of PROTACs.
Description

L-Homopropargylglycine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor.
In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

Chemical Information

CAS Number

98891-36-2
Formula Weight

127.14
Molecular Formula

C6H9NO2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (1966.34 mM; Ultrasonic )
SMILES

N[C@@H](CCC#C)C(O)=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562?

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