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Grapiprant

CAS No. 415903-37-6

Grapiprant( CJ-023423 | AAT-007 )

Catalog No. M14424 CAS No. 415903-37-6

A novel EP4 antagonist; an analgesic and anti-inflammatory drug in the piprant class that was approved for Veterinary Medicine for the control of pain and inflammation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 110 Get Quote
25MG 177 Get Quote
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Biological Information

  • Product Name
    Grapiprant
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel EP4 antagonist; an analgesic and anti-inflammatory drug in the piprant class that was approved for Veterinary Medicine for the control of pain and inflammation.
  • Description
    A novel EP4 antagonist; an analgesic and anti-inflammatory drug in the piprant class that was approved for Veterinary Medicine for the control of pain and inflammation associated with osteoarthritis (OA) in dogs.Pain Phase 2 Clinical(In Vivo):Grapiprant (0-50 mg/kg; oral administration; every 24 hours; for 9 months; beagles) is safe for dogs by long-term oral administration. Efficacy of Grapiprant in the treatment of dogs with osteoarthritis needs to be evaluated in other studies.
  • In Vitro
    ——
  • In Vivo
    Grapiprant (0-50 mg/kg; oral administration; every 24 hours; for 9 months; beagles) is safe for dogs by long-term oral administration. Efficacy of Grapiprant in the treatment of dogs with osteoarthritis needs to be evaluated in other studies . Animal Model:36 beagles of both sexes (9-month-old) Dosage:0 mg/kg, 1 mg/kg, 6 mg/kg, or 50 mg/kg Administration:Oral administration; every 24 hours; for 9 months Result:Long-term oral administration was safe for dogs.
  • Synonyms
    CJ-023423 | AAT-007
  • Pathway
    GPCR/G Protein
  • Target
    Prostaglandin Receptor
  • Recptor
    Prostaglandin Receptor
  • Research Area
    Neurological Disease
  • Indication
    Pain

Chemical Information

  • CAS Number
    415903-37-6
  • Formula Weight
    491.6052
  • Molecular Formula
    C26H29N5O3S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(NCCC1=CC=C(C=C1)N2C(CC)=NC3=C(N=C(C=C32)C)C)NS(C4=CC=C(C=C4)C)(=O)=O
  • Chemical Name
    Benzenesulfonamide, N-[[[2-[4-(2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]ethyl]amino]carbonyl]-4-methyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rausch-Derra LC, et al. Am J Vet Res. 2015 Oct;76(10):853-9. 2. Rausch-Derra LC, et al. J Vet Pharmacol Ther. 2016 Dec;39(6):566-571. 3. De Vito V, et al. J Pharm Biomed Anal. 2016 Jan 25;118:251-8.
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