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Home - Products - Wnt/Notch/Hedgehog - Dishevelled - KY-02061

KY-02061

CAS No. 2093406-88-1

KY-02061( KY02061 )

Catalog No. M13287 CAS No. 2093406-88-1

KY-02061 is a small-molecule inhibitor of Dishevelled-CXXC5 interaction with IC50 of 24 uM in vitro binding assay.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    KY-02061
  • Note
    Research use only, not for human use.
  • Brief Description
    KY-02061 is a small-molecule inhibitor of Dishevelled-CXXC5 interaction with IC50 of 24 uM in vitro binding assay.
  • Description
    KY-02061 is a small-molecule inhibitor of Dishevelled-CXXC5 interaction with IC50 of 24 uM in vitro binding assay; increases the activation of the Wnt/β-catenin pathway in a dose-dependent manner as revealed by the TOPflash reporter assay, ALP activity also increased in a dose‐dependent manner in KY-02061-treated primary osteoblast cells, increases levels of Runx2, an osteoblast differentiation marker, and β-catenin.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    KY02061
  • Pathway
    Wnt/Notch/Hedgehog
  • Target
    Dishevelled
  • Recptor
    Dishevelled
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2093406-88-1
  • Formula Weight
    445.486
  • Molecular Formula
    C22H23NO7S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    ethyl 1-(2-ethoxy-2-oxoethyl)-5-(tosyloxy)-1H-indole-2-carboxylate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kim HY, et al. EMBO Mol Med. 2016 Apr 1;8(4):375-87.
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