Cart
sales@molnova.com
KUNB 31
CAS No. 2220263-80-7
KUNB 31( KUNB31 )
Catalog No. M13541 CAS No. 2220263-80-7
KUNB 31 is a potent, isoform-selective Hsp90β inhibitor with Kd of 0.18 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 963 | Get Quote |
|
| 50MG | 1962 | Get Quote |
|
| 100MG | 2520 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameKUNB 31
-
NoteResearch use only, not for human use.
-
Brief DescriptionKUNB 31 is a potent, isoform-selective Hsp90β inhibitor with Kd of 0.18 uM.
-
DescriptionKUNB 31 is a potent, isoform-selective Hsp90β inhibitor with Kd of 0.18 uM, displays 50-fold selectivity over Hsp90α and Grp94; exhibits anti-proliferative activity against NCI H23, UC3, and HT-29 cancer cell lines with IC50 of 6.74 μM, 3.01 μM, and 3.72 μM, respectively; specificly induces the degradation of Hsp90β-dependent client proteins (EGFR, HER2, CDK4, CDK6, CXCR4 etc.) in cells.
-
In Vitro——
-
In Vivo——
-
SynonymsKUNB31
-
PathwayCytoskeleton/Cell Adhesion Molecules
-
TargetHSP
-
RecptorHSP
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2220263-80-7
-
Formula Weight322.364
-
Molecular FormulaC19H18N2O3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(C1=CC(C(C)C)=C(ON=C2)C2=C1O)N3CC4=C(C=CC=C4)C3
-
Chemical Name(4-hydroxy-7-isopropylbenzo[d]isoxazol-5-yl)(isoindolin-2-yl)methanone
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Khandelwal A, et al. Nat Commun. 2018 Jan 30;9(1):425.
molnova catalog
related products
-
p5 Ligand for Dnak a...
p5 Ligand for Dnak and DnaJ is a non-apeptide and correspond to the main binding sites of the 23 residues of the mitochondrial aspartate aminotransferase presequence.P5 ligand is a high affinity ligand for Dnak and DnaJ.
-
MPC-0767
MPC-0767 (MPC0767, MPC3100 mesylate hydrate) is an L-alanine ester prodrug of MPC-3100.
-
Eupalinolide A(b)
Eupalinolide B is a natural product and demonstrates potent cytotoxicity against A-549 BGC-823 SMMC-7721 and HL-60 tumour cell lines.
