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KU-0063794
CAS No. 938440-64-3
KU-0063794( KU 0063794 | KU0063794 )
Catalog No. M16720 CAS No. 938440-64-3
A potent, specific, cell permeant inhibitor of mTOR with IC50 of 10 nM for both mTORC1 and mTORC2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 50 | In Stock |
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| 5MG | 49 | In Stock |
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| 10MG | 68 | In Stock |
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| 25MG | 125 | In Stock |
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| 50MG | 217 | In Stock |
|
| 100MG | 402 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 913 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameKU-0063794
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, specific, cell permeant inhibitor of mTOR with IC50 of 10 nM for both mTORC1 and mTORC2.
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DescriptionA potent, specific, cell permeant inhibitor of mTOR with IC50 of 10 nM for both mTORC1 and mTORC2; displays no activity against 76 other protein kinases or seven lipid kinases, including class 1 PI3Ks (>1,000-fold); suppresses activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK, also inhibits phosphorylation of the T-loop Thr308 of Akt, induces complete dephosphorylation of 4E-BP1 in HEK-293 cells; suppresses cell growth and induces G1-cell cycle arrest in both wild-type and mLST8 deficient MEFs.
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In Vitro——
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In Vivo——
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SynonymsKU 0063794 | KU0063794
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PathwayPI3K/Akt/mTOR signaling
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TargetmTOR
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RecptormTORC1|mTORC2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number938440-64-3
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Formula Weight465.5447
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Molecular FormulaC25H31N5O4
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESOCC1=CC(C2=NC3=NC(N4C[C@@H](C)O[C@@H](C)C4)=NC(N5CCOCC5)=C3C=C2)=CC=C1OC
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Chemical NameBenzenemethanol, 5-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-, rel-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. García-Martínez JM, et al. Biochem J. 2009 Jun 12;421(1):29-42.
2. Malagu K, et al. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5950-3.
3. Syed F, et al. J Invest Dermatol. 2013 May;133(5):1340-50.
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