KNI-1657 ( KNI1657 )

Catalog No. M17096 CAS No.

COA

Datasheet

HNMR

HPLC

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Product Name

KNI-1657
Note

Research use only, not for human use.
Brief Description

KNI-1657 (KNI1657) is a highly potent HIV-1 protease inhibitor (97% inhibition at 1 nM) with high sensitivity against lopinavir/ritonavir- or darunavir-resistant strains.
Description

KNI-1657 (KNI1657) is a highly potent HIV-1 protease inhibitor (97% inhibition at 1 nM) with high sensitivity against lopinavir/ritonavir- or darunavir-resistant strains; inhibits wild-type HIV-1 (pNL4-3) and LPV-resistant strain A17 with IC50 of <3 and 25 nM, respectively.
Synonyms

KNI1657
Pathway

Microbiology/Virology
Target

HIV
Recptor

HIV
Research Area

——
Indication

——

CAS Number

--
Formula Weight

756.92
Molecular Formula

C41H48N4O8S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C([C@H]1N(C([C@@H](O)[C@@H](NC([C@@H](NC(C2=CC3=CC=CC(OC)=C3O2)=O)[C@@H]4COCC4)=O)CC5=CC=CC=C5)=O)CSC1(C)C)NCC6=C(C)C=CC=C6C
Chemical Name

(R)-N-(2,6-dimethylbenzyl)-3-((2S,3S)-2-hydroxy-3-((S)-2-(7-methoxybenzofuran-2-carboxamido)-2-((R)-tetrahydrofuran-3-yl)acetamido)-4-phenylbutanoyl)-5,5-dimethylthiazolidine-4-carboxamide

1. Hidaka K, et al. J Med Chem. 2018 May 31. doi: 10.1021/acs.jmedchem.7b01709.

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