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KL1333

CAS No. 1800405-30-4

KL1333( NQO1 activator 1 )

Catalog No. M23811 CAS No. 1800405-30-4

KL1333 enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    KL1333
  • Note
    Research use only, not for human use.
  • Brief Description
    KL1333 enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts.
  • Description
    KL1333 enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD(P)H: NQO1 as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NQO1 activator 1
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    NADPH
  • Recptor
    NQO1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1800405-30-4
  • Formula Weight
    240.26
  • Molecular Formula
    C14H12N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:245 mg/mL (1019.73 mM; Need ultrasonic)
  • SMILES
    CC(C)c1nc(-c(cccc2)c2C(C2=O)=O)c2[nH]1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Seo KS, et al. KL1333, a Novel NAD+ Modulator, Improves Energy Metabolism and Mitochondrial Dysfunction in MELAS Fibroblasts. Front Neurol. 2018 Jul 5;9:552.
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