KI16

CAS No. 1090696-43-7

KI16 ( KI 16 )

Catalog No. M10344 CAS No. 1090696-43-7

KI16 is a novel small molecules that inhibit STAT3-dependent transcription and function.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    KI16
  • Note
    Research use only, not for human use.
  • Brief Description
    KI16 is a novel small molecules that inhibit STAT3-dependent transcription and function.
  • Description
    KI16 is a novel small molecules that inhibit STAT3-dependent transcription and function, interacts with the STAT3 SH2 domain; inhibits STAT3 phosphorylation and transcriptional activity in response to IL6 stimulation, inhibits cell viability preferentially in STAT3-dependent cell lines.
  • Synonyms
    KI 16
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1090696-43-7
  • Formula Weight
    328.30
  • Molecular Formula
    C14H8N4O4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1C(=O)NC2=C(O1)C=CC(=C2)SC3=C(C=C(C=N3)[N+](=O)[O-])C#N
  • Chemical Name
    5-nitro-2-((3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)thio)nicotinonitrile

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kolosenko I, et al. PLoS One. 2017 Jun 21;12(6):e0178844.
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