Cart
sales@molnova.com
KHK-IN-1
CAS No. 1303469-70-6
KHK-IN-1( Ketohexokinase inhibitor 8 | KHK-IN-8 )
Catalog No. M26731 CAS No. 1303469-70-6
KHK-IN-1 is a reversible and ATP-competitive inhibitor of ketohexokinase (KHK) with IC50 of 12 nM. In the ATP-binding region of KHK, KHK-IN-1 interacts with Asp-27B.
KHK-IN-1 is a reversible and ATP-competitive inhibitor of ketohexokinase (KHK) with IC50 of 12 nM. In the ATP-binding region of KHK, KHK-IN-1 interacts with Asp-27B.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 336 | Get Quote |
|
| 10MG | 500 | Get Quote |
|
| 25MG | 806 | Get Quote |
|
| 50MG | 1098 | Get Quote |
|
| 100MG | 1485 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameKHK-IN-1
-
NoteResearch use only, not for human use.
-
Brief DescriptionKHK-IN-1 is a reversible and ATP-competitive inhibitor of ketohexokinase (KHK) with IC50 of 12 nM. In the ATP-binding region of KHK, KHK-IN-1 interacts with Asp-27B.
-
DescriptionKHK-IN-1 is a reversible and ATP-competitive inhibitor of ketohexokinase (KHK) with IC50 of 12 nM. In the ATP-binding region of KHK, KHK-IN-1 interacts with Asp-27B.
-
In VitroKHK-IN-1 stable in human and rat liver microsome preparations (88 and 72% remaining at 10 min) and do not significantly inhibit cytochrome P450s from human liver microsomes (1A2, 2C19, 2D6, 2C9, and 3A4).KHK-IN-1 (0-10 μM; incubate 30 min, then add to 15 mM fructose and incubate for another 3 h) inhibits production of F1P in HepG2 cell lysates with an IC50 value of 400 nM. Cell Viability Assay Cell Line:HepG2 cells Concentration:0-10 μM Incubation Time:Incubate 30 min, then add to 15 mM fructose and incubate for another 3 h Result:Exhibited inhibition of F1P production in HepG2 cell lysates (IC50=400 nM).
-
In VivoKHK-IN-1 (10 mg/kg; p.o.; single) shows oral bioavailability of 34% in rats. Animal Model:Male Sprague-Dawley rats (~250 g).Dosage:10 mg/kg Administration:Oral gavage; single Result:Exhibited reasonable oral bioavailability in rats (F=34%; oral t1/2=4 h), but had a high volume of distribution (Vdss= 32 L/kg) and a high rate of clearance (CL=160 mL/min/kg).
-
SynonymsKetohexokinase inhibitor 8 | KHK-IN-8
-
PathwayOthers
-
TargetOther Targets
-
RecptorGLP-1
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1303469-70-6
-
Formula Weight422.56
-
Molecular FormulaC21H26N8S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCSc1ccccc1Nc1nc(nc2c(NCC3CC3)ncnc12)N1CCNCC1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
-
Acetyl shikonin
Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and angiogenic factors.
-
Lactoferrin (17-41) ...
This is amino acids 17 to 41 fragment of lactoferrin, known as lactoferricin B. This peptide shows anti-fungal properties in combination of other anti-fungal agents.Candida Albicans is one of the targets of the lactoferricin B.
-
8-Prenylkaempferol
8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory agent for suppressing influenza A virus-induced RANTES production acts by blocking PI3K-mediated transcriptional activation of NF-κB and IRF-3 and in part by interfering with IκB degradation which subsequently decreases NF-κB translocation.
