KH7 ( KH-7;KH 7;sAC inhibitor KH7 )

Catalog No. M14099 CAS No. 330676-02-3

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Product Name

KH7
Note

Research use only, not for human use.
Brief Description

A potent, specific soluble adenylyl cyclase (sAC) inhibitor that inhibits Mn2+-dependent sAC with IC50 of 2.7 uM.
Description

A potent, specific soluble adenylyl cyclase (sAC) inhibitor that inhibits Mn2+-dependent sAC with IC50 of 2.7 uM; inhibits physiologically stimulated sAC with similar potency with IC50 of 8.0 uM, completely blocks the capacitation-induced rise in cAMP in wild-type sperm at 10 uM, inhibits in vitro fertilization.
Synonyms

KH-7;KH 7;sAC inhibitor KH7
Pathway

Metabolic Enzyme/Protease
Target

Adenylate Cyclase
Recptor

Adenylate Cyclase
Research Area

——
Indication

——

CAS Number

330676-02-3
Formula Weight

419.30
Molecular Formula

C17H15BrN4O2S
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 100 mg/mL 238.49 mM; H2O : < 0.1 mg/mL
SMILES

CC(SC1=NC2=CC=CC=C2N1)C(N/N=C/C3=CC(Br)=CC=C3O)=O
Chemical Name

(E)-2-((1H-benzo[d]imidazol-2-yl)thio)-N'-(5-bromo-2-hydroxybenzylidene)propanehydrazide

1. Bitterman JL, et al. J Pharmacol Exp Ther. 2013 Dec;347(3):589-98.
2. Hess KC, et al. Dev Cell. 2005 Aug;9(2):249-59.

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