
KH-176
CAS No. 1541170-75-5
KH-176( Sonlicromanol | KH176 )
Catalog No. M12178 CAS No. 1541170-75-5
KH-176 (KH176, Sonlicromanol) is a smal molecule ROS-redox modulator.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 873 | Get Quote |
![]() ![]() |
50MG | 1782 | Get Quote |
![]() ![]() |
100MG | 2250 | Get Quote |
![]() ![]() |
200MG | Get Quote | Get Quote |
![]() ![]() |
500MG | Get Quote | Get Quote |
![]() ![]() |
1G | Get Quote | Get Quote |
![]() ![]() |
Biological Information
-
Product NameKH-176
-
NoteResearch use only, not for human use.
-
Brief DescriptionKH-176 (KH176, Sonlicromanol) is a smal molecule ROS-redox modulator.
-
DescriptionKH-176 (KH176, Sonlicromanol) is a smal molecule ROS-redox modulator, effectively reduces increased cellular ROS levels and protects OXPHOS deficient primary cells against redox perturbation by targeting the Thioredoxin/Peroxiredoxin system; significantly improves rotarod and gait performance and reduces the degeneration of retinal ganglion cells in Ndufs4 -/- mice, shows therapeutic effects in mammalian model of Leigh Disease.
-
In Vitro——
-
In VivoSonlicromanol (KH176, 10 mg/kg, ip, twice daily) has promising, but independent and nonadditive, properties for the pharmacological treatment of CI-deficiency-related mitochondrial diseases. Animal Model:Ndufs4?/? mice.Dosage:10 mg/kg.Administration:Twice daily by intraperitoneal injection.Result:Increased lifespan of Ndufs4?/? mice similar as KH176 and Clofibrate single treatment.
-
SynonymsSonlicromanol | KH176
-
PathwayApoptosis
-
TargetAdenosine Receptor
-
RecptorAdenosine Receptor
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1541170-75-5
-
Formula Weight332.444
-
Molecular FormulaC19H28N2O3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCC1=C(O)C(C)=C2CC[C@@](C)(C(N[C@@H]3CCCNC3)=O)OC2=C1C
-
Chemical Name(2S)-6-hydroxy-2,5,7,8-tetramethyl-N-[(3R)-piperidin-3-yl]-3,4-dihydro-2H-1-benzopyran-2-carboxamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. de Haas R, et al. Sci Rep. 2017 Sep 15;7(1):11733.
2. Koene S, et al. Orphanet J Rare Dis. 2017 Oct 16;12(1):163.
3. Beyrath J, et al. Sci Rep. 2018 Apr 26;8(1):6577.
molnova catalog



related products
-
Solabegron
Solabegron is a selective agonist of β3-adrenergic receptor, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR(EC50 : 22 nM). It is used for treatment of overactive bladder and irritable bowel syndrome.
-
Piclidenoson
Piclidenoson a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM) induces robust anti-inflammatory effect in psoriasis patients.
-
ST-4206
A metabolite of ST1535, which is potent, selective A2A adenosine receptor antagonist with Ki of 6.6 nM.