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KH-176

CAS No. 1541170-75-5

KH-176( Sonlicromanol | KH176 )

Catalog No. M12178 CAS No. 1541170-75-5

KH-176 (KH176, Sonlicromanol) is a smal molecule ROS-redox modulator.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    KH-176
  • Note
    Research use only, not for human use.
  • Brief Description
    KH-176 (KH176, Sonlicromanol) is a smal molecule ROS-redox modulator.
  • Description
    KH-176 (KH176, Sonlicromanol) is a smal molecule ROS-redox modulator, effectively reduces increased cellular ROS levels and protects OXPHOS deficient primary cells against redox perturbation by targeting the Thioredoxin/Peroxiredoxin system; significantly improves rotarod and gait performance and reduces the degeneration of retinal ganglion cells in Ndufs4 -/- mice, shows therapeutic effects in mammalian model of Leigh Disease.
  • In Vitro
    ——
  • In Vivo
    Sonlicromanol (KH176, 10 mg/kg, ip, twice daily) has promising, but independent and nonadditive, properties for the pharmacological treatment of CI-deficiency-related mitochondrial diseases. Animal Model:Ndufs4?/? mice.Dosage:10 mg/kg.Administration:Twice daily by intraperitoneal injection.Result:Increased lifespan of Ndufs4?/? mice similar as KH176 and Clofibrate single treatment.
  • Synonyms
    Sonlicromanol | KH176
  • Pathway
    Apoptosis
  • Target
    Adenosine Receptor
  • Recptor
    Adenosine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1541170-75-5
  • Formula Weight
    332.444
  • Molecular Formula
    C19H28N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1=C(O)C(C)=C2CC[C@@](C)(C(N[C@@H]3CCCNC3)=O)OC2=C1C
  • Chemical Name
    (2S)-6-hydroxy-2,5,7,8-tetramethyl-N-[(3R)-piperidin-3-yl]-3,4-dihydro-2H-1-benzopyran-2-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. de Haas R, et al. Sci Rep. 2017 Sep 15;7(1):11733. 2. Koene S, et al. Orphanet J Rare Dis. 2017 Oct 16;12(1):163. 3. Beyrath J, et al. Sci Rep. 2018 Apr 26;8(1):6577.
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