Cart
sales@molnova.com
Home - Products - Apoptosis - Adenosine Receptor - KH-176

KH-176

CAS No. 1541170-75-5

KH-176( Sonlicromanol | KH176 )

Catalog No. M12178 CAS No. 1541170-75-5

KH-176 (KH176, Sonlicromanol) is a smal molecule ROS-redox modulator.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 873 Get Quote
50MG 1782 Get Quote
100MG 2250 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    KH-176
  • Note
    Research use only, not for human use.
  • Brief Description
    KH-176 (KH176, Sonlicromanol) is a smal molecule ROS-redox modulator.
  • Description
    KH-176 (KH176, Sonlicromanol) is a smal molecule ROS-redox modulator, effectively reduces increased cellular ROS levels and protects OXPHOS deficient primary cells against redox perturbation by targeting the Thioredoxin/Peroxiredoxin system; significantly improves rotarod and gait performance and reduces the degeneration of retinal ganglion cells in Ndufs4 -/- mice, shows therapeutic effects in mammalian model of Leigh Disease.
  • In Vitro
    ——
  • In Vivo
    Sonlicromanol (KH176, 10 mg/kg, ip, twice daily) has promising, but independent and nonadditive, properties for the pharmacological treatment of CI-deficiency-related mitochondrial diseases. Animal Model:Ndufs4?/? mice.Dosage:10 mg/kg.Administration:Twice daily by intraperitoneal injection.Result:Increased lifespan of Ndufs4?/? mice similar as KH176 and Clofibrate single treatment.
  • Synonyms
    Sonlicromanol | KH176
  • Pathway
    Apoptosis
  • Target
    Adenosine Receptor
  • Recptor
    Adenosine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1541170-75-5
  • Formula Weight
    332.444
  • Molecular Formula
    C19H28N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1=C(O)C(C)=C2CC[C@@](C)(C(N[C@@H]3CCCNC3)=O)OC2=C1C
  • Chemical Name
    (2S)-6-hydroxy-2,5,7,8-tetramethyl-N-[(3R)-piperidin-3-yl]-3,4-dihydro-2H-1-benzopyran-2-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. de Haas R, et al. Sci Rep. 2017 Sep 15;7(1):11733. 2. Koene S, et al. Orphanet J Rare Dis. 2017 Oct 16;12(1):163. 3. Beyrath J, et al. Sci Rep. 2018 Apr 26;8(1):6577.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Adenosine amine cong...

    Adenosine amine congener (ADAC) is an agonist of selective A1 adenosine receptor.

  • Guanabenz hydrochlor...

    Guanabenz hydrochloride is an orally active α2-adrenoceptor agonist with hypotensive effects.

  • Solabegron

    Solabegron is a selective agonist of β3-adrenergic receptor, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR(EC50 : 22 nM). It is used for treatment of overactive bladder and irritable bowel syndrome.

Sign In Join Free