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KH-176
CAS No. 1541170-75-5
KH-176( Sonlicromanol | KH176 )
Catalog No. M12178 CAS No. 1541170-75-5
KH-176 (KH176, Sonlicromanol) is a smal molecule ROS-redox modulator.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameKH-176
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NoteResearch use only, not for human use.
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Brief DescriptionKH-176 (KH176, Sonlicromanol) is a smal molecule ROS-redox modulator.
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DescriptionKH-176 (KH176, Sonlicromanol) is a smal molecule ROS-redox modulator, effectively reduces increased cellular ROS levels and protects OXPHOS deficient primary cells against redox perturbation by targeting the Thioredoxin/Peroxiredoxin system; significantly improves rotarod and gait performance and reduces the degeneration of retinal ganglion cells in Ndufs4 -/- mice, shows therapeutic effects in mammalian model of Leigh Disease.
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In Vitro——
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In VivoSonlicromanol (KH176, 10 mg/kg, ip, twice daily) has promising, but independent and nonadditive, properties for the pharmacological treatment of CI-deficiency-related mitochondrial diseases. Animal Model:Ndufs4?/? mice.Dosage:10 mg/kg.Administration:Twice daily by intraperitoneal injection.Result:Increased lifespan of Ndufs4?/? mice similar as KH176 and Clofibrate single treatment.
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SynonymsSonlicromanol | KH176
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PathwayApoptosis
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TargetAdenosine Receptor
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RecptorAdenosine Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1541170-75-5
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Formula Weight332.444
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Molecular FormulaC19H28N2O3
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=C(O)C(C)=C2CC[C@@](C)(C(N[C@@H]3CCCNC3)=O)OC2=C1C
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Chemical Name(2S)-6-hydroxy-2,5,7,8-tetramethyl-N-[(3R)-piperidin-3-yl]-3,4-dihydro-2H-1-benzopyran-2-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. de Haas R, et al. Sci Rep. 2017 Sep 15;7(1):11733.
2. Koene S, et al. Orphanet J Rare Dis. 2017 Oct 16;12(1):163.
3. Beyrath J, et al. Sci Rep. 2018 Apr 26;8(1):6577.
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