Solabegron

CAS No. 252920-94-8

Solabegron( GW 427353 )

Catalog No. M24143 CAS No. 252920-94-8

Solabegron is a selective agonist of β3-adrenergic receptor, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR(EC50 : 22 nM). It is used for treatment of overactive bladder and irritable bowel syndrome.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 250 In Stock
10MG 410 In Stock
25MG 745 In Stock
50MG 1008 In Stock
100MG 1341 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Solabegron
  • Note
    Research use only, not for human use.
  • Brief Description
    Solabegron is a selective agonist of β3-adrenergic receptor, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR(EC50 : 22 nM). It is used for treatment of overactive bladder and irritable bowel syndrome.
  • Description
    Solabegron is a selective agonist of β3-adrenergic receptor, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR(EC50 : 22 nM). It is used for treatment of overactive bladder and irritable bowel syndrome. (In Vivo):Solabegron (GW427353) at 3 mg/kg i.v. evokes an increase in micturition volume threshold that prevented the acetic acid-evoked decreases in dogs. The low dose (1 mg/kg) shows no significant activity.
  • In Vitro
    ——
  • In Vivo
    Solabegron (GW427353) at 3 mg/kg i.v. evokes an increase in micturition volume threshold that prevented the acetic acid-evoked decreases in dogs. The low dose (1 mg/kg) shows no significant activity. Animal Model:Adult female beagle dogs (6-10 kg).Dosage:1, 3 mg/kg.Administration:I.V. once.Result:Dosage of 3 mg/kg evoked an increase in micturition volume threshold.
  • Synonyms
    GW 427353
  • Pathway
    Apoptosis
  • Target
    Adenosine Receptor
  • Recptor
    β3-adrenergic receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    252920-94-8
  • Formula Weight
    410.89
  • Molecular Formula
    C23H23ClN2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:250 mg/mL (608.44 mM; Need ultrasonic)
  • SMILES
    C1=CC(=CC(=C1)C(=O)O)C2=CC(=CC=C2)NCCNC[C@@H](C3=CC(=CC=C3)Cl)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hicks A, et al. GW427353 (solabegron), a novel, selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog. J Pharmacol Exp Ther. 2007 Oct;323(1):202-9.
molnova catalog
related products
  • ST-4206

    A metabolite of ST1535, which is potent, selective A2A adenosine receptor antagonist with Ki of 6.6 nM.

  • Rolofylline

    A potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM.

  • SCH 442416

    SCH-442416 is an selective antagonist of adenosine A2A receptor.?SCH-442416 binds to human and rat A2A receptors with high affinity (Ki values are 0.048 and 0.5 nM respectively).The A2A receptor antagonist (SCH 442416) could increase mRNA expression of the Kir 2.1and Kir 4.1 channels in Müller cells to protect the retinal neurons in vitro under hypoxic conditions.