Solabegron

CAS No. 252920-94-8

Solabegron( GW 427353 )

Catalog No. M24143 CAS No. 252920-94-8

Solabegron is a selective agonist of β3-adrenergic receptor, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR(EC50 : 22 nM). It is used for treatment of overactive bladder and irritable bowel syndrome.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 250 In Stock
10MG 410 In Stock
25MG 745 In Stock
50MG 1008 In Stock
100MG 1341 In Stock
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Biological Information

  • Product Name
    Solabegron
  • Note
    Research use only, not for human use.
  • Brief Description
    Solabegron is a selective agonist of β3-adrenergic receptor, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR(EC50 : 22 nM). It is used for treatment of overactive bladder and irritable bowel syndrome.
  • Description
    Solabegron is a selective agonist of β3-adrenergic receptor, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR(EC50 : 22 nM). It is used for treatment of overactive bladder and irritable bowel syndrome. (In Vivo):Solabegron (GW427353) at 3 mg/kg i.v. evokes an increase in micturition volume threshold that prevented the acetic acid-evoked decreases in dogs. The low dose (1 mg/kg) shows no significant activity.
  • In Vitro
    ——
  • In Vivo
    Solabegron (GW427353) at 3 mg/kg i.v. evokes an increase in micturition volume threshold that prevented the acetic acid-evoked decreases in dogs. The low dose (1 mg/kg) shows no significant activity. Animal Model:Adult female beagle dogs (6-10 kg).Dosage:1, 3 mg/kg.Administration:I.V. once.Result:Dosage of 3 mg/kg evoked an increase in micturition volume threshold.
  • Synonyms
    GW 427353
  • Pathway
    Apoptosis
  • Target
    Adenosine Receptor
  • Recptor
    β3-adrenergic receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    252920-94-8
  • Formula Weight
    410.89
  • Molecular Formula
    C23H23ClN2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:250 mg/mL (608.44 mM; Need ultrasonic)
  • SMILES
    C1=CC(=CC(=C1)C(=O)O)C2=CC(=CC=C2)NCCNC[C@@H](C3=CC(=CC=C3)Cl)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hicks A, et al. GW427353 (solabegron), a novel, selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog. J Pharmacol Exp Ther. 2007 Oct;323(1):202-9.
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