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KCI807

CAS No. 6665-68-5

KCI807( KCI-807 | KCI 807 )

Catalog No. M15543 CAS No. 6665-68-5

KCI807 (KCI-807) is a lead molecule that selectively disrupts ELK1-dependent promoter activation by wild-type and variant Ars (IC50=0.53 uM).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    KCI807
  • Note
    Research use only, not for human use.
  • Brief Description
    KCI807 (KCI-807) is a lead molecule that selectively disrupts ELK1-dependent promoter activation by wild-type and variant Ars (IC50=0.53 uM).
  • Description
    KCI807 (KCI-807) is a lead molecule that selectively disrupts ELK1-dependent promoter activation by wild-type and variant Ars (IC50=0.53 uM) without interfering with ELK1 activation by ERK; binds to AR (Kd=69.2 nM), blocking ELK1 binding, and selectively blocks recruitment of AR to chromatin by ELK1; primarily affects a subset of AR target growth genes selectively suppressing AR-dependent growth of PC cell lines with a better inhibitory profile than Enzalutamide; also inhibits in vivo growth of castration/enzalutamide-resistant cell line-derived and patient-derived tumor xenografts.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    KCI-807 | KCI 807
  • Pathway
    Endocrinology/Hormones
  • Target
    Androgen Receptor (AR)
  • Recptor
    Androgen Receptor (AR)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    6665-68-5
  • Formula Weight
    254.241
  • Molecular Formula
    C15H10O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1=CC(=CC(=C1)O)C2=CC(=O)C3=C(C=CC=C3O2)O
  • Chemical Name
    5-hydroxy-2-(3-hydroxyphenyl)-4H-chromen-4-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rosati R, et al. Clin Cancer Res. 2018 Sep 5. pii: clincanres.0982.2018. doi: 10.1158/1078-0432.CCR-18-0982.
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