Drospirenone

Research use only, not for human use.

Drospirenone is a synthetic progestin that is an analog to spironolactone. It is found in a number of birth control formulations.

Drospirenone is a synthetic progestin that is an analog to spironolactone. It is found in a number of birth control formulations. Drospirenone differs from other synthetic progestins in that its pharmacological profile in preclinical studies shows it to be closer to the natural progesterone. As such it has anti-mineralocorticoid properties, counteracts the estrogen-stimulated activity of the renin-angiotensin-aldosterone system, and is not androgenic. It was shown in animal studies that drospirenone exhibits antiandrogenic activity judging from accessory sex gland growth in castrated, androgen-treated, juvenile rats.

1,2-dihydro Spirorenone; ZK 30595

Endocrinology/Hormones

Androgen Receptor (AR)

Androgen Receptor; COX-2; PR; Mineralocorticoid Receptor

Endocrinology

——

67392-87-4

366.49

C24H30O3

>98%(HPLC)

Ethanol: 11 mg/mL (30.01 mM); DMSO: 73 mg/mL (199.18 mM)

O=C1CC[C@]2(C)[C@@]3([H])CC[C@@]([C@](OC4=O)(CC4)[C@]5([H])[C@@]6([H])C5)(C)[C@]6([H])[C@]3([H])C7C(C7)C2=C1

(2'S,4aR,4bS,6aS,7aS,8aS,8bS,8cR,8dR,9aR)-4a,6a-dimethyl-4,4a,4b,5,6,6a,7a,8,8a,8b,8c,8d,9,9a-tetradecahydro-3'H-spiro[cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-7,2'-furan]-2,5'(3H,4'H)-dione

(-20℃)

With Ice Pack

≥ 2 years