Drospirenone

Research use only, not for human use.

Drospirenone is a synthetic progestin that is an analog to spironolactone. It is found in a number of birth control formulations.

Drospirenone is a synthetic progestin that is an analog to spironolactone. It is found in a number of birth control formulations. Drospirenone differs from other synthetic progestins in that its pharmacological profile in preclinical studies shows it to be closer to the natural progesterone. As such it has anti-mineralocorticoid properties, counteracts the estrogen-stimulated activity of the renin-angiotensin-aldosterone system, and is not androgenic. It was shown in animal studies that drospirenone exhibits antiandrogenic activity judging from accessory sex gland growth in castrated, androgen-treated, juvenile rats.

Cell Cytotoxicity Assay Cell Line:PLHC-1 cell Concentration:10-150 μM Incubation Time:24 h, 48 h Result:Caused a 50% decline in cell viability with the effective concentration of 102-119 μM after 24 h exposure and 51-58 μM after 48 h exposure.

Animal Model:Adult female mice Dosage:10 mg/kg, 100mg/kg Administration:Oral gavage (p.o.)Result:Caused DNA damage at dose rates of 10 and 100 mg/kg.Enhanced the genotoxicity combinated with ethinylestradiol.

1,2-dihydro Spirorenone | ZK 30595

Endocrinology/Hormones

Androgen Receptor (AR)

Androgen Receptor| COX-2| PR| Mineralocorticoid Receptor

Endocrinology

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67392-87-4

366.49

C24H30O3

>98% (HPLC)

Ethanol: 11 mg/mL (30.01 mM); DMSO: 73 mg/mL (199.18 mM)

O=C1CC[C@]2(C)[C@@]3([H])CC[C@@]([C@](OC4=O)(CC4)[C@]5([H])[C@@]6([H])C5)(C)[C@]6([H])[C@]3([H])C7C(C7)C2=C1

(2'S,4aR,4bS,6aS,7aS,8aS,8bS,8cR,8dR,9aR)-4a,6a-dimethyl-4,4a,4b,5,6,6a,7a,8,8a,8b,8c,8d,9,9a-tetradecahydro-3'H-spiro[cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-7,2'-furan]-2,5'(3H,4'H)-dione

(-20℃)

With Ice Pack

≥ 2 years