Drospirenone

CAS No. 67392-87-4

Drospirenone( 1,2-dihydro Spirorenone | ZK 30595 )

Catalog No. M15569 CAS No. 67392-87-4

Drospirenone is a synthetic progestin that is an analog to spironolactone. It is found in a number of birth control formulations.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 70 In Stock
50MG 120 In Stock
100MG 195 In Stock
200MG 291 In Stock
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Biological Information

  • Product Name
    Drospirenone
  • Note
    Research use only, not for human use.
  • Brief Description
    Drospirenone is a synthetic progestin that is an analog to spironolactone. It is found in a number of birth control formulations.
  • Description
    Drospirenone is a synthetic progestin that is an analog to spironolactone. It is found in a number of birth control formulations. Drospirenone differs from other synthetic progestins in that its pharmacological profile in preclinical studies shows it to be closer to the natural progesterone. As such it has anti-mineralocorticoid properties, counteracts the estrogen-stimulated activity of the renin-angiotensin-aldosterone system, and is not androgenic. It was shown in animal studies that drospirenone exhibits antiandrogenic activity judging from accessory sex gland growth in castrated, androgen-treated, juvenile rats.
  • In Vitro
    Cell Cytotoxicity Assay Cell Line:PLHC-1 cell Concentration:10-150 μM Incubation Time:24 h, 48 h Result:Caused a 50% decline in cell viability with the effective concentration of 102-119 μM after 24 h exposure and 51-58 μM after 48 h exposure.
  • In Vivo
    Animal Model:Adult female mice Dosage:10 mg/kg, 100mg/kg Administration:Oral gavage (p.o.)Result:Caused DNA damage at dose rates of 10 and 100 mg/kg.Enhanced the genotoxicity combinated with ethinylestradiol.
  • Synonyms
    1,2-dihydro Spirorenone | ZK 30595
  • Pathway
    Endocrinology/Hormones
  • Target
    Androgen Receptor (AR)
  • Recptor
    Androgen Receptor| COX-2| PR| Mineralocorticoid Receptor
  • Research Area
    Endocrinology
  • Indication
    ——

Chemical Information

  • CAS Number
    67392-87-4
  • Formula Weight
    366.49
  • Molecular Formula
    C24H30O3
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 11 mg/mL (30.01 mM); DMSO: 73 mg/mL (199.18 mM)
  • SMILES
    O=C1CC[C@]2(C)[C@@]3([H])CC[C@@]([C@](OC4=O)(CC4)[C@]5([H])[C@@]6([H])C5)(C)[C@]6([H])[C@]3([H])C7C(C7)C2=C1
  • Chemical Name
    (2'S,4aR,4bS,6aS,7aS,8aS,8bS,8cR,8dR,9aR)-4a,6a-dimethyl-4,4a,4b,5,6,6a,7a,8,8a,8b,8c,8d,9,9a-tetradecahydro-3'H-spiro[cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthrene-7,2'-furan]-2,5'(3H,4'H)-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bray JD, et al. J Steroid Biochem Mol Biol. 2005 Dec;97(4):328-4
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