Cart
sales@molnova.com
Home - Products - Cytoskeleton/Cell Adhesion Molecules - HSP - KBU2046

KBU2046

CAS No. 1143863-69-7

KBU2046( KBU 2046 | KBU-2046 )

Catalog No. M10511 CAS No. 1143863-69-7

KBU2046 (KBU-2046) is a highly selective inhibitor of metastasis, binds to and stabilizes CDC37/HSP90β heterocomplexes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 43 Get Quote
5MG 72 Get Quote
10MG 102 Get Quote
25MG 215 Get Quote
50MG 335 Get Quote
100MG 507 Get Quote
500MG 1062 Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    KBU2046
  • Note
    Research use only, not for human use.
  • Brief Description
    KBU2046 (KBU-2046) is a highly selective inhibitor of metastasis, binds to and stabilizes CDC37/HSP90β heterocomplexes.
  • Description
    KBU2046 (KBU-2046) is a highly selective inhibitor of metastasis, binds to and stabilizes CDC37/HSP90β heterocomplexes; selectively disrupts heterocomplex function and inhibits cancer cell motility, only binds to HSP90β and CDC37 when both proteins are present, does not bind to either protein alone; decreases phosphorylation of HSP90β, inhibits cancer metastasis and prolongs life in vivo; KBU2046-mediated changes in the signature of client proteins bound to the HSP90β/CDC37 heterocomplex mediate effects upon cell motility.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    KBU 2046 | KBU-2046
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    HSP
  • Recptor
    HSP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1143863-69-7
  • Formula Weight
    242.249
  • Molecular Formula
    C15H11FO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (206.40 mM)
  • SMILES
    O=C1C(C2=CC=C(F)C=C2)COC3=C1C=CC=C3
  • Chemical Name
    3-(4-fluorophenyl)chroman-4-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Xu L, et al. Nat Commun. 2018 Jun 22;9(1):2454.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • KUNB 31

    KUNB 31 is a potent, isoform-selective Hsp90β inhibitor with Kd of 0.18 uM.

  • AMP-PCP

    AMP-PCP is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of Hsp90.

  • Arimoclomol

    Arimoclomol is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (ALS).

Sign In Join Free