K03861
CAS No. 853299-07-7
K03861 ( AUZ454; AUZ 454; AUZ-454; K03861 )
Catalog No. M17620 CAS No. 853299-07-7
K03861 is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 39 | In Stock |
|
5MG | 65 | In Stock |
|
10MG | 105 | In Stock |
|
25MG | 222 | In Stock |
|
50MG | 335 | In Stock |
|
100MG | 537 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
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Biological Information
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Product NameK03861
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NoteResearch use only, not for human use.
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Brief DescriptionK03861 is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.
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DescriptionAUZ454 is a potent and selective Type II FLT3 inhibitor. AUZ454 is able to override drug resistance that less potent "type I" inhibitors and "type II" first-generation FLT3 inhibitors cannot. Constitutively activated mutant FLT3 has emerged as a promising target for therapy for the subpopulation of acute myeloid leukemia (AML) patients who harbor it. The small molecule inhibitor, PKC412, targets mutant FLT3 and is currently in late-stage clinical trials. However, the identification of PKC412-resistant leukemic blast cells in the bone marrow of AML patients has propelled the development of novel and structurally distinct FLT3 inhibitors that have the potential to override drug resistance and more efficiently prevent disease progression or recurrence.
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SynonymsAUZ454; AUZ 454; AUZ-454; K03861
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PathwayOthers
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TargetOther Targets
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RecptorCDK2(A144C); CDK2(C118L); CDK2(C118L/A144C); CDK2(WT)
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number853299-07-7
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Formula Weight501.5
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Molecular FormulaC24H26F3N7O2
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Purity98%
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SolubilityDMSO : ≥ 33 mg/mL; 65.80 mM
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SMILESCN1CCN(CC2=CC=C(NC(=O)NC3=CC=C(OC4=NC(N)=NC=C4)C=C3)C=C2C(F)(F)F)CC1
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Chemical Name1-(4-((2-aminopyrimidin-4-yl)oxy)phenyl)-3-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)urea
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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