K03861

CAS No. 853299-07-7

K03861 ( AUZ454; AUZ 454; AUZ-454; K03861 )

Catalog No. M17620 CAS No. 853299-07-7

K03861 is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 39 In Stock
5MG 65 In Stock
10MG 105 In Stock
25MG 222 In Stock
50MG 335 In Stock
100MG 537 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    K03861
  • Note
    Research use only, not for human use.
  • Brief Description
    K03861 is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.
  • Description
    AUZ454 is a potent and selective Type II FLT3 inhibitor. AUZ454 is able to override drug resistance that less potent "type I" inhibitors and "type II" first-generation FLT3 inhibitors cannot. Constitutively activated mutant FLT3 has emerged as a promising target for therapy for the subpopulation of acute myeloid leukemia (AML) patients who harbor it. The small molecule inhibitor, PKC412, targets mutant FLT3 and is currently in late-stage clinical trials. However, the identification of PKC412-resistant leukemic blast cells in the bone marrow of AML patients has propelled the development of novel and structurally distinct FLT3 inhibitors that have the potential to override drug resistance and more efficiently prevent disease progression or recurrence.
  • Synonyms
    AUZ454; AUZ 454; AUZ-454; K03861
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    CDK2(A144C); CDK2(C118L); CDK2(C118L/A144C); CDK2(WT)
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    853299-07-7
  • Formula Weight
    501.5
  • Molecular Formula
    C24H26F3N7O2
  • Purity
    98%
  • Solubility
    DMSO : ≥ 33 mg/mL; 65.80 mM
  • SMILES
    CN1CCN(CC2=CC=C(NC(=O)NC3=CC=C(OC4=NC(N)=NC=C4)C=C3)C=C2C(F)(F)F)CC1
  • Chemical Name
    1-(4-((2-aminopyrimidin-4-yl)oxy)phenyl)-3-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)urea

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

molnova catalog
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