kaempferide

Research use only, not for human use.

Kaempferide triglycoside inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by ligand binding dependent estrogen receptor activation.

Kaempferide triglycoside inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by ligand binding dependent estrogen receptor activation.

Western Blot Analysis Cell Line:HepG2Concentration:5 μM, 10 μM, 20 μM . Before treatment with OA (HY-N1446) (0.5 mM; 48 h)Incubation Time:48 h Result:Lowered the expression of proteins related to fat production, including sterol regulatory element-binding protein 1 (SREBP1), fatty acid synthase (FAS), and stearoyl-CoA desaturase 1 (SCD-1).Reduced the expression of two adipogenic transcription factors, peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT enhancer-binding protein β (C/EBPβ).Enhanced the expression of heme oxygenase-1 (HO-1) and nuclear factor erythroid 2-related factor 2 (Nrf2).

Animal Model:High-fat diet male C57BL/6J mice modelDosage:10 mg/kg Administration:Supplemented in daily diet, once daily for16 weeksResult:Reduced the weight, organ weight, and index of mice.Lowered the levels of glycolipids in mouse serum.Decreased the expression levels of inflammatory-related genes, including NF-κB, IL-6, ICAM-1, VCAM-1, and TNF-α.Animal Model:Ischemia/Reperfusion (I/R) SD rat model.Dosage:0.1 mg/kg, 0.3 mg/kg, 3 mg/kg Administration:Injection, Single dose. Before the I/R injury induced by Coronary Artery Ligation (CAL) in SD rats.Result:Significantly improved heart function, reduced myocardial injury by reducing myocardial enzyme levels, and dose-dependently reduced the area of myocardial infarction in rats.Significantly decreased serum levels of TNF-α, IL-6, C-reactive protein (CRP), MDA, and ROS, while increasing serum levels of SOD.Downregulated the expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and cleaved caspase-3, and upregulated the phosphorylation expression levels of phospho-Akt (p-Akt) and phospho-glycogen synthase kinase-3β (p-GSK-3β).

Kaempferide

Others

Other Targets

ER

Others-Field

——

491-54-3

300.27

C16H12O6

>98% (HPLC)

DMSO : 20 mg/mL 66.61 mM;

COc1ccc(cc1)c1c(c(=O)c2c(cc(cc2o1)O)O)O

3,5,7-trihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one

(-20℃)

With Ice Pack

≥ 2 years