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Jaceosidin
CAS No. 18085-97-7
Jaceosidin( 4'-Demethyleupatilin | Jaseocidin )
Catalog No. M12770 CAS No. 18085-97-7
Jaceosidin (4'-Demethyleupatilin, Jaseocidin) is a trihydroxyflavone that exhibits anti-allergic, anti-inflammatory and apoptosis inducing activties.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 113 | In Stock |
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| 10MG | 177 | In Stock |
|
| 25MG | 357 | In Stock |
|
| 50MG | 534 | In Stock |
|
| 100MG | 762 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameJaceosidin
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NoteResearch use only, not for human use.
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Brief DescriptionJaceosidin (4'-Demethyleupatilin, Jaseocidin) is a trihydroxyflavone that exhibits anti-allergic, anti-inflammatory and apoptosis inducing activties.
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DescriptionJaceosidin (4'-Demethyleupatilin, Jaseocidin) is a trihydroxyflavone that exhibits anti-allergic, anti-inflammatory and apoptosis inducing activties; promotes angiogenesis via activation of VEGFR2/FAK/PI3K/AKT/NF-κB signaling pathways in endothelial cells; shows selective suppression of proliferation (IC50 = 82.1?μM in HSC-3 cells and 97.5?μM in Ca9.22 cells) and accumulation of cells at the sub-G1 stage of the cell cycle, induces apoptotic cell death and inhibits the Akt pathway in oral cancer cells.
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In VitroCell Viability Assay Cell Line:Hec1A, KLE, HES and HESC cells Concentration:3.125, 6.25, 12.5, 25, 50, and 100 μM Incubation Time:48 hour Result:Showed cytostatic activity to HES and HESC cells with IC50s of 52.68 and 55.10 μM, less cytotocxic on Hec1 A and KLE (IC50, 70.54, 147.14 μM).
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In VivoAnimal Model:5-week-old male BALB/c mice (23-26 g) Dosage:10 and 20 mg/kg Administration:P.O. once a day for 3 days Result:Decreased the volumes of exudates (inflammatory markers), cell number and protein levels. Inhibited TNF-α by 46.7% and 50.8%, IL-1β by 46.0% and 44.7%, and PGE2 by 21.7% and 16.9%, respectively, at 20 mg/kg. Blocked COX-2 expression and NF-κB activation.Animal Model:Male Sprague-Dawley rats (180-200 g)Dosage:20 mg/kg Administration:P.O., for 2 hour Result:Reduced hind paw edema volume by 27.1% at 1 h, and 24.0% at 2 h, respectively.
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Synonyms4'-Demethyleupatilin | Jaseocidin
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PathwayNatural Products
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TargetFlavonoids
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RecptorUGT
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number18085-97-7
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Formula Weight330.292
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Molecular FormulaC17H14O7
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Purity>98% (HPLC)
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SolubilityDMSO: Soluble （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=C1C=C(C2=CC=C(O)C(OC)=C2)OC3=CC(O)=C(OC)C(O)=C13
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Chemical Name5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxychromen-4-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lee HG, et al. J Ethnopharmacol. 2005 Apr 26;98(3):339-43.
2. Han HY, et al. Evid Based Complement Alternat Med. 2018 May 13;2018:5765047.
3. Allison BJ, et al. Nat Prod Res. 2017 Mar;31(6):707-712.
4. Lee TH, et al. Exp Biol Med (Maywood). 2014 Oct;239(10):1325-34.
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