Isobavachalcone

Research use only, not for human use.

Isobavachalcone (Corylifolinin, Isobacachalcone) is a chalcone constituent of Angelica keiskei that can induce apoptosis in several cancer cells, also shows activity against multidrug-resistant (MDR) Gram-negative bacterial isolates.

Isobavachalcone (Corylifolinin, Isobacachalcone) is a chalcone constituent of Angelica keiskei that can induce apoptosis in several cancer cells, also shows activity against multidrug-resistant (MDR) Gram-negative bacterial isolates; significantly reduces pro-caspase-3 and pro-caspase-9, and subsequently increases the level of cleaved caspase-3 and cleaved caspase-9 in neuroblastoma cell lines also exhibiting deletions of the major efflux pump components (AcrAB, TolC).

Cell Proliferation Assay Cell Line:OVCAR-8, PC3, A549, MCF-7, L-02 and HUVEC cells Concentration:6.0-48.0 μM Incubation Time:72 hours Result:Inhibited the proliferation of human cancer cells.Western Blot Analysis Cell Line:OVCAR-8 or PC3 cells Concentration:0 μM, 6 μM, 12 μM, and 18 μM Incubation Time:6 hours Result:A concentration-and time-dependent down-regulation of the Ser-473 phosphorylation of Akt. GSK3b phosphorylation was also inhibited in a concentration- and time-dependent manner.Apoptosis Analysis Cell Line:OVCAR-8 cells and PC3 cells Concentration:0 μM, 6 μM, 12 μM, and 18 μM Incubation Time:72 hours Result:Led to dose dependent increase of apoptosis.

Animal Model:Seven-week-old specific pathogen-free female Kunming mice (18-22 g)Dosage:20 mg/kg Administration:Intraperitoneal injection; for 0.5, 1, 2, 4, 6, 8, 12, 24 hours Result:Increased in blood glucose levels.

Corylifolinin | Isobacachalcone

Natural Products

Flavonoids

Others

Cancer

——

20784-50-3

324.3704

C20H20O4

>98% (HPLC)

DMSO: 11 mg/mL

O=C(C1=CC=C(O)C(C/C=C(C)\C)=C1O)/C=C/C2=CC=C(O)C=C2

2-Propen-1-one, 1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-, (2E)-

(-20℃)

With Ice Pack

≥ 2 years