JNK-IN-7 ( JNK-IN-7; JNK inhibitor;JNKIN7; JNK IN 7 )

Catalog No. M17280 CAS No. 1408064-71-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

JNK-IN-7
Note

Research use only, not for human use.
Brief Description

JNK-IN-7 is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM). It can also inhibit phosphorylation of c-Jun, which is a substrate of JNK kinase.
Description

JNK-IN-7 is a relatively selective JNKs inhibitor(IC50= 1.54/1.99/0.75 for JNK1/2/3); also bound to IRAK1, PIK3C3, PIP5K3 and PIP4K2C.
Synonyms

JNK-IN-7; JNK inhibitor;JNKIN7; JNK IN 7
Pathway

Others
Target

Other Targets
Recptor

JNK1; JNK2; JNK3
Research Area

Inflammation/Immunology
Indication

——

CAS Number

1408064-71-0
Formula Weight

493.56
Molecular Formula

C28H27N7O2
Purity

98%
Solubility

DMSO : 33.33 mg/mL. 67.53 mM; H2O : < 0.1 mg/mL
SMILES

C(=O)(Nc1cccc(c1)C(=O)Nc1ccc(cc1)Nc1nccc(n1)c1cnccc1)/C=C/CN(C)C
Chemical Name

3-[[(E)-4-(Dimethylamino)but-2-enoyl]amino]-N-[4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide

1. Zhang T, et al. Chem Biol, 2012, 19(1): 140-154.

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