
JNK-IN-7
CAS No. 1408064-71-0
JNK-IN-7( JNK-IN-7 | JNK inhibitor | JNKIN7 | JNK IN 7 )
Catalog No. M17280 CAS No. 1408064-71-0
JNK-IN-7 is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM). It can also inhibit phosphorylation of c-Jun, which is a substrate of JNK kinase.
Purity : >98% (HPLC)






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Biological Information
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Product NameJNK-IN-7
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NoteResearch use only, not for human use.
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Brief DescriptionJNK-IN-7 is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM). It can also inhibit phosphorylation of c-Jun, which is a substrate of JNK kinase.
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DescriptionJNK-IN-7 is a relatively selective JNKs inhibitor(IC50= 1.54/1.99/0.75 for JNK1/2/3); also bound to IRAK1, PIK3C3, PIP5K3 and PIP4K2C.(In Vitro):JNK-IN-7 is a relatively selective JNK inhibitor in cells. In addition to JNK 1, 2, 3, JNK-IN-7 also binds to IRAK1(IC50=14.1 nM), YSK4 (IC50=4.8 nM), ERK3 (IC50=22 nM), PIK3C3, PIP5K3 and PIP4K2C. Expression of divalent metal-ion transporter 1 (DMT1) in HCT116 is demonstrated to be markedly decreased under stimulation with TNF for 24 and 48 h, while JNK-IN-7 can significantly reverse the decrease. TNF can down-regulate DMT1 expression, while JNK-IN-7 can markedly suppress this function.
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In VitroJNK-IN-7 is a relatively selective JNK inhibitor in cells. In addition to JNK 1, 2, 3, JNK-IN-7 also binds to IRAK1(IC50=14.1 nM), YSK4 (IC50=4.8 nM), ERK3 (IC50=22 nM), PIK3C3, PIP5K3 and PIP4K2C. Expression of divalent metal-ion transporter 1 (DMT1) in HCT116 is demonstrated to be markedly decreased under stimulation with TNF for 24 and 48 h, while JNK-IN-7 can significantly reverse the decrease. TNF can down-regulate DMT1 expression, while JNK-IN-7 can markedly suppress this function.
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In Vivo——
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SynonymsJNK-IN-7 | JNK inhibitor | JNKIN7 | JNK IN 7
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PathwayOthers
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TargetOther Targets
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RecptorJNK1| JNK2| JNK3
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number1408064-71-0
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Formula Weight493.56
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Molecular FormulaC28H27N7O2
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Purity>98% (HPLC)
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SolubilityDMSO : 33.33 mg/mL. 67.53 mM; H2O : < 0.1 mg/mL
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SMILESC(=O)(Nc1cccc(c1)C(=O)Nc1ccc(cc1)Nc1nccc(n1)c1cnccc1)/C=C/CN(C)C
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Chemical Name3-[[(E)-4-(Dimethylamino)but-2-enoyl]amino]-N-[4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhang T, et al. Chem Biol, 2012, 19(1): 140-154.
molnova catalog



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