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Home - Products - Membrane Transporter/Ion Channel - iGluR - JNJ-61432059

JNJ-61432059

CAS No. 2035814-50-5

JNJ-61432059( —— )

Catalog No. M26724 CAS No. 2035814-50-5

JNJ-61432059 is an oral active and selective negative modulator of TARP γ?8 Selective AMPAR(pIC50: 9.7).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    JNJ-61432059
  • Note
    Research use only, not for human use.
  • Brief Description
    JNJ-61432059 is an oral active and selective negative modulator of TARP γ?8 Selective AMPAR(pIC50: 9.7).
  • Description
    JNJ-61432059 is an oral active and selective negative modulator of TARP γ?8 Selective AMPAR(pIC50: 9.7).(In Vivo):In mouse hippocampus, Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    iGluR
  • Recptor
    SHMT1| SHMT2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2035814-50-5
  • Formula Weight
    443.482
  • Molecular Formula
    C25H22FN5O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (112.75 mM)
  • SMILES
    OC1CCN(CC1)c1nccc2c(c(nn12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ducker GS, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409.
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