Cart
sales@molnova.com
BPAM344
CAS No. 1204572-55-3
BPAM344( —— )
Catalog No. M23375 CAS No. 1204572-55-3
BPAM344 is a potent positive allosteric modulator (PAM) of the KAR subunits GluK1b, GluK2a, and GluK3a.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 76 | In Stock |
|
| 10MG | 125 | In Stock |
|
| 25MG | 267 | In Stock |
|
| 50MG | 483 | In Stock |
|
| 100MG | 698 | In Stock |
|
| 500MG | 1431 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameBPAM344
-
NoteResearch use only, not for human use.
-
Brief DescriptionBPAM344 is a potent positive allosteric modulator (PAM) of the KAR subunits GluK1b, GluK2a, and GluK3a.
-
DescriptionBPAM344 is a potent positive allosteric modulator (PAM) of the KAR subunits GluK1b, GluK2a, and GluK3a.
-
In VitroBPAM344 potentiates glutamate-evoked currents of GluK2a 21-fold at the highest concentration tested (200 μM), with an EC50 of 79 μM. BPAM344 markedly decreases desensitization kinetics (from 5.5 to 775 ms), whereas it only has a minor effect on deactivation kinetics. BPAM344 (100 μM) also potentiates the peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fold).
-
In Vivo——
-
Synonyms——
-
PathwayMembrane Transporter/Ion Channel
-
TargetiGluR
-
RecptorKainate receptor
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1204572-55-3
-
Formula Weight242.27
-
Molecular FormulaC10H11FN2O2S
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 250 mg/mL (1031.91 mM)
-
SMILESFC1=CC=C(C2=C1)N(C3CC3)CNS2(=O)=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Larsen A P , Fievre S , Frydenvang K , et al. Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors[J]. Molecular Pharmacology, 2017:mol.116.107599.
molnova catalog
related products
-
NS-1209
A selective, water-soluble, in vivo long-lasting AMPA antagonist with Ki of 43 nM; display selectivity for the [3H] AMPA over the [3H]kainate- (IC50=81 uM), [3H]CGS19755, and [3H]glycine-binding sites (IC50 > 30 uM) in rat cortical membranes.
-
BDZ-g
BDZ-g is a potent and selective antagonist of AMPA receptor. BDZ-g can be used for the research of various neurological disorders involving excessive activity of AMPA receptors.
-
Traxoprodil
A potent and NR2B-selective NMDA receptor antagonist; potently protects cultured hippocampal neurons from glutamate toxicity (IC50=10 nM).
