Cart
sales@molnova.com
JNJ-40411813
CAS No. 1127498-03-6
JNJ-40411813( JNJ40411813 | ADX 71149 )
Catalog No. M10446 CAS No. 1127498-03-6
A novel potent positive allosteric modulator of mGlu2 with EC50 of 147 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 222 | In Stock |
|
| 10MG | 354 | In Stock |
|
| 25MG | 592 | In Stock |
|
| 50MG | 843 | In Stock |
|
| 100MG | 1143 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameJNJ-40411813
-
NoteResearch use only, not for human use.
-
Brief DescriptionA novel potent positive allosteric modulator of mGlu2 with EC50 of 147 nM.
-
DescriptionA novel potent positive allosteric modulator of mGlu2 with EC50 of 147 nM; displays >30-fold selectivity over mGlu1 and mGlu3-8, 10-fold over 5-HT2A; displays an optimal interplay between potency, selectivity, favorable ADMET/PK and cardiovascular safety profile, and central EEG activity; has been investigated in the clinic for schizophrenia and anxious depression disorders.Epilepsy Phase 2 Clinical.
-
In Vitro——
-
In Vivo——
-
SynonymsJNJ40411813 | ADX 71149
-
PathwayGPCR/G Protein
-
TargetmGluR
-
RecptormGluR
-
Research AreaNeurological Disease
-
IndicationEpilepsy
Chemical Information
-
CAS Number1127498-03-6
-
Formula Weight344.883
-
Molecular FormulaC20H25ClN2O
-
Purity>98% (HPLC)
-
SolubilityDMSO : 25 mg/mL 72.49 mM
-
SMILESClC1=C(N2CCC(C3=CC=CC=C3)CC2)C=CN(CCCC)C1=O
-
Chemical Name1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Cid JM, et al. J Med Chem. 2014 Aug 14;57(15):6495-512.
2. Ahnaou A, et al. Neuropharmacology. 2016 Apr;103:290-305.
3. Lavreysen H, et al. Pharmacol Res Perspect. 2015 Mar;3(2):e00097.
4. Kent JM, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2016 Jun 3;67:66-73.
molnova catalog
related products
-
LY-404039
A potent, slective agonist of mGlu2 and mGlu3 receptors with Ki of 149 nM and 92 nM, respectively.
-
JNJ-40411813
A novel potent positive allosteric modulator of mGlu2 with EC50 of 147 nM.
-
Curdione
Curdione inhibits CYP3A4 activity and the production of prostaglandin E2. Curdione inhibits proliferation of MCF-7 cells by inducing apoptosis.
