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JMJD7-IN-1

CAS No. 311316-96-8

JMJD7-IN-1( Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester )

Catalog No. M24241 CAS No. 311316-96-8

JMJD7-IN-1 is a potent?JMJD7?inhibitor, with an?IC50?of 6.62 μM. JMJD7-IN-1 shows good inhibitory activity against cells expressing a high level of JMJD7.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    JMJD7-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    JMJD7-IN-1 is a potent?JMJD7?inhibitor, with an?IC50?of 6.62 μM. JMJD7-IN-1 shows good inhibitory activity against cells expressing a high level of JMJD7.
  • Description
    JMJD7-IN-1 is a potent?JMJD7?inhibitor, with an?IC50?of 6.62 μM. JMJD7-IN-1 shows good inhibitory activity against cells expressing a high level of JMJD7.
  • In Vitro
    JMJD7-IN-1 (0.1-1000 μM) dose-dependently inhibits the activity of JMJD7, with an IC50 of 6.62 μM.JMJD7-IN-1 efficiently binds to JMJD7, with an IC50 of 3.80 μM.JMJD7-IN-1 (72 h) inhibits the growth of T-47d, SK-BR-3, Jurkat and Hela cells, with IC50s of 9.40 μM, 13.26 μM, 15.03 μM and 16.14 μM, respectively.
  • In Vivo
    ——
  • Synonyms
    Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    JMJD7
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    311316-96-8
  • Formula Weight
    363.15
  • Molecular Formula
    C16H8Cl2N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    O=C(OC1=C2N=CC=CC2=C([N+]([O-])=O)C=C1)C3=CC=C(Cl)C=C3Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Zhang W, et, al. Discovery of JMJD7 inhibitors with the aid of virtual screening and bioactivity evaluation. Bioorg Med Chem Lett. 2021 May 25;45:128139.
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