Cart
sales@molnova.com
JCN037
CAS No. 2305154-31-6
JCN037 ( —— )
Catalog No. M21982 CAS No. 2305154-31-6
JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 132 | Get Quote |
|
| 10MG | 205 | Get Quote |
|
| 25MG | 344 | Get Quote |
|
| 50MG | 511 | Get Quote |
|
| 100MG | 734 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameJCN037
-
NoteResearch use only, not for human use.
-
Brief DescriptionJCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).
-
DescriptionJCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).Relative to the conventional EGFR TKIs erlotinib and lapatinib, JCN037 displayed potent activity against EGFR amplified/mutant patient-derived cell cultures, significant BBB penetration (2:1 brain-to-plasma ratio), and superior efficacy in an EGFR-driven orthotopic glioblastoma xenograft model.
-
Synonyms——
-
PathwayAngiogenesis
-
TargetEGFR
-
RecptorEGFR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2305154-31-6
-
Formula Weight376.18
-
Molecular FormulaC16H11BrFN3O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESFc1c(Br)cccc1Nc1ncnc2cc3OCCOc3cc12
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Jonathan E. Tsang, et al. Development of a Potent Brain-Penetrant EGFR Tyrosine Kinase Inhibitor against Malignant Brain Tumors. ACS Med. Chem. Lett. 2020. May 1.
molnova catalog
related products
-
Desmethyl Erlotinib
OSI-420 is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).
-
Naquotinib mesylate
Naquotinib (ASP-8273) is a potent, irreversible, mutant-selective inhibitor of EGFR.
-
ICA-105574
ICA-105574 is an activator of hERG that binds to the channel to remove inactivation, thus increasing peak current amplitude and shortening the action potential. It also modulates activation kinetics of the channel.
