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JAS239
CAS No. 1630288-74-2
JAS239( JAS 239 | JAS-239 )
Catalog No. M12448 CAS No. 1630288-74-2
JAS239 is a novel carbocyanine dye that binds and competitively inhibits choline kinase (ChoK) intracellularly.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameJAS239
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NoteResearch use only, not for human use.
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Brief DescriptionJAS239 is a novel carbocyanine dye that binds and competitively inhibits choline kinase (ChoK) intracellularly.
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DescriptionJAS239 is a novel carbocyanine dye that binds and competitively inhibits choline kinase (ChoK) intracellularly, prevents choline phosphorylation and induces cell death in breast cancer cell lines; inhibits the phosphorylation of 14C-labeled choline in MDA-MB-231 triple-negative breast cancer cells with IC50 of 4.6 uM, significant reduces MDA-MB-231 viability with IC50 of 13.3 uM; a NIR-fluorescent ChoK inhibitor.
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In Vitro——
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In Vivo——
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SynonymsJAS 239 | JAS-239
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PathwayOthers
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TargetChoK
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RecptorChoK
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Research Area——
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Indication——
Chemical Information
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CAS Number1630288-74-2
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Formula Weight505.099
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Molecular FormulaC31H37ClN2O2
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1(C)C(/C=C/C=C/C=C/C=C2N(CCO)C3=C(C=CC=C3)C/2(C)C)=[N+](CCO)C4=C1C=CC=C4.[Cl-]
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Chemical Name1-(2-hydroxyethyl)-2-((1E,3E,5E)-7-((Z/E)-1-(2-hydroxyethyl)-3,3-dimethylindolin-2-ylidene)hepta-1,3,5-trien-1-yl)-3,3-dimethyl-3H-indol-1-ium chloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Arlauckas SP, et al. Mol Cancer Ther. 2014 Sep;13(9):2149-58.
2. Arlauckas SP, et al. Oncotarget. 2017 Mar 7;8(10):16518-16530.
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