JAK-IN-35

Research use only, not for human use.

JAK-IN-35 is a potent and efficacious dual JAK1/JAK3 inhibitor with IC50 of 0.9/1.9 nM.

JAK-IN-35 is a potent and efficacious dual JAK1/JAK3 inhibitor with IC50 of 0.9/1.9 nM; shows weak activity against TYK2 and JAK2 (IC50=25 nM and15 nM respectively), also inhibits both ROCK1 (IC50=95 nM) and ROCK2 (IC50=43 nM); inhibits JAK1/3 mediated ex vivo processes in the mouse PD model (EC50 67 ± 13 nM); shows potential cardiovascular liabilities, specifically, QT interval prolongation.

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Angiogenesis

JAK

JAK

Inflammation/Immunology

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1400687-19-5

408.506

C22H28N6O2

>98% (HPLC)

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CC1(C(CCC1(C)N)NC2=C(C=NN3C2=CC(=C3)C4=CN=C(C=C4)OC)C(=O)N)C

4-(((1R,3S)-3-amino-2,2,3-trimethylcyclopentyl)amino)-6-(6-methoxypyridin-3-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide

(-20℃)

With Ice Pack

≥ 2 years