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NIBR-3049

CAS No. 1260181-14-3

NIBR-3049( TCS-21311 )

Catalog No. M11072 CAS No. 1260181-14-3

NIBR-3049 (TCS-21311) is a potent, highly selective JAK3 inhibitor with IC50 of 8 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NIBR-3049
  • Note
    Research use only, not for human use.
  • Brief Description
    NIBR-3049 (TCS-21311) is a potent, highly selective JAK3 inhibitor with IC50 of 8 nM.
  • Description
    NIBR-3049 (TCS-21311) is a potent, highly selective JAK3 inhibitor with IC50 of 8 nM, displays >100-fold selectivity over JAK1, JAK2 and TYK2, also inhibits PKCα, PKCθ, and GSK3β with IC50 of 13, 68, and 3 nM, respectively.
  • In Vitro
    TCS 21311 (NIBR3049) exhibits IC50 values of 1.017, 2.550 and 8.055 μM for JAK1, JAK2 and TYK2, respectively?in a enzymatic Jak assay.TCS 21311 (NIBR3049) shows moderate activity in this cellular assay (IC50=689 nM, Jurkat cells), which is in good agreement with its enzymatic Pkc activity.
  • In Vivo
    ——
  • Synonyms
    TCS-21311
  • Pathway
    Angiogenesis
  • Target
    JAK
  • Recptor
    JAK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1260181-14-3
  • Formula Weight
    526.51
  • Molecular Formula
    C27H25F3N4O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (189.93 mM)
  • SMILES
    O=C(C(C1=CC(N2CCN(C(C(C)(O)C)=O)CC2)=CC=C1C(F)(F)F)=C3C4=CNC5=C4C=CC=C5)NC3=O
  • Chemical Name
    3-[5-[4-(2-Hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Thoma G, et al. J Med Chem. 2011 Jan 13;54(1):284-8.
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