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Itaconate-alkyne

CAS No. 2454181-83-8

Itaconate-alkyne( ITalk )

Catalog No. M28361 CAS No. 2454181-83-8

Itaconate-alkyne is a bioorthogonal probe for quantitative and site-specific chemoproteomic profiling of itaconate in inflammatory macrophages and enables biochemical evaluation and proteomic analysis of its direct targets.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Itaconate-alkyne
  • Note
    Research use only, not for human use.
  • Brief Description
    Itaconate-alkyne is a bioorthogonal probe for quantitative and site-specific chemoproteomic profiling of itaconate in inflammatory macrophages and enables biochemical evaluation and proteomic analysis of its direct targets.
  • Description
    Itaconate-alkyne is a bioorthogonal probe for quantitative and site-specific chemoproteomic profiling of itaconate in inflammatory macrophages and enables biochemical evaluation and proteomic analysis of its direct targets.(In Vitro):Itaconate-alkyne can capture itaconate targets including DNA damage-binding protein 1 (DDB1), Gelsolin (GSN), ATP-citrate synthase (ACLY) and Adenylate kinase 2 (AK2) in inflammatory macrophages.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ITalk
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2454181-83-8
  • Formula Weight
    238.28
  • Molecular Formula
    C13H18O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (1049.19 mM)
  • SMILES
    O=C(O)C(=C)CC(=O)OCCCCCCC#C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Daly JW, et al. Structure-activity relationships for N6-substituted adenosines at a brain A1-adenosine receptor with a comparison to an A2-adenosine receptor regulating coronary blood flow. Biochem Pharmacol. 1986 Aug 1;35(15):2467-81.
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