Isothiafludine
CAS No. 960527-22-4
Isothiafludine ( NZ-4 )
Catalog No. M16861 CAS No. 960527-22-4
Isothiafludine (NZ-4) is a novel HBV capsid assembly inhibitor that inhibits HBV replication through blocking pregenomic RNA encapsidation, suppresses HBV replication in HepG2.2.15 cells with IC50 of 1.33 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 873 | Get Quote |
|
50MG | 1782 | Get Quote |
|
100MG | 2250 | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameIsothiafludine
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NoteResearch use only, not for human use.
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Brief DescriptionIsothiafludine (NZ-4) is a novel HBV capsid assembly inhibitor that inhibits HBV replication through blocking pregenomic RNA encapsidation, suppresses HBV replication in HepG2.2.15 cells with IC50 of 1.33 uM.
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DescriptionIsothiafludine (NZ-4) is a novel HBV capsid assembly inhibitor that inhibits HBV replication through blocking pregenomic RNA encapsidation, suppresses HBV replication in HepG2.2.15 cells with IC50 of 1.33 uM; shows activity against the replication of various drug-resistant HBV mutants, including 3TC/ETV-dual-resistant and ADV-resistant HBV mutants; concentration-dependently reduces the encapsidated HBV pgRNA, resulting in the assembly of replication-deficient capsids in HepG2.2.15 cells; inhibits DHBV DNA replication in the DHBV-infected ducks after oral administration.HBV Infection Phase 1 Clinical
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SynonymsNZ-4
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PathwayMicrobiology/Virology
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TargetHBV
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RecptorHBV
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Research AreaInfection
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IndicationHBV Infection
Chemical Information
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CAS Number960527-22-4
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Formula Weight375.48
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Molecular FormulaC18H18FN3OS2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C1=C(CC(C)C)SC(C2=NC=CS2)=N1)NCC3=CC=C(F)C=C3
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Chemical NameN-[(4-Fluorophenyl)methyl]-5-(2-methylpropyl)[2,2'-bithiazole]-4-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yang L, et al. Acta Pharmacol Sin. 2014 Mar;35(3):410-8.
2. Yang L, et al. Antiviral Res. 2016 Jan;125:25-33.
2. Yang L, et al. Antiviral Res. 2016 Jan;125:25-33.
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