Cart
sales@molnova.com
Isomangiferin
CAS No. 24699-16-9
Isomangiferin( —— )
Catalog No. M13720 CAS No. 24699-16-9
Isomangiferin is the major tetracyclic oxindole alkaloid components of Uncaira species, inhibits NMDA receptor with IC50 of 43.2 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 110 | In Stock |
|
| 10MG | 178 | In Stock |
|
| 25MG | 296 | In Stock |
|
| 50MG | 443 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameIsomangiferin
-
NoteResearch use only, not for human use.
-
Brief DescriptionIsomangiferin is the major tetracyclic oxindole alkaloid components of Uncaira species, inhibits NMDA receptor with IC50 of 43.2 uM.
-
DescriptionIsomangiferin is the major tetracyclic oxindole alkaloid components of Uncaira species, inhibits NMDA receptor with IC50 of 43.2 uM, also blocks calcium channel; also effectively blocks the EphA4-dependent signaling in hippocampal neurons, reduces the EphA4 activity effectively in the hippocampus of APP/PS1 transgenic mice after oral administration, restores the impaired long-term potentiation in transgenic mouse models of AD.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayMembrane Transporter/Ion Channel
-
TargetiGluR
-
RecptorAntiviral|Free radical scavengers
-
Research AreaInfection
-
Indication——
Chemical Information
-
CAS Number24699-16-9
-
Formula Weight422.3396
-
Molecular FormulaC19H18O11
-
Purity>98% (HPLC)
-
SolubilityDMSO: 10 mM （ < 1 mg/ml refers to the product slightly soluble or insoluble )
-
SMILESC1=C2C(=CC(=C1O)O)OC3=C(C2=O)C(=CC(=C3C4C(C(C(C(O4)CO)O)O)O)O)O
-
Chemical Name4-beta-D-Glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.?Kang TH, et al. Eur J Pharmacol. 2002 Nov 22;455(1):27-34.
2.?Kang TH, et al. Life Sci. 2004 Dec 3;76(3):331-43.
3.?Fu AK, et al. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9959-64.
molnova catalog
related products
-
Zonampanel
Zonampanel (YM 872) is a selective, potent and highly water-soluble, competitive AMPA receptor (AMPAR) antagonist with Ki of 96 nM.
-
Eliprodil
Eliprodil (SL-820715) is a non-competitive NR2B-NMDA receptor antagonist, less potent for NR2A- and NR2C-containing receptors (IC50>100 uM).
-
Dalzanemdor
Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dysfunction.
