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Isolongifolene
CAS No. 1135-66-6
Isolongifolene( (-)-Isolongifolene )
Catalog No. M23324 CAS No. 1135-66-6
Isolongifolene has antioxidant, anti-inflammatory, anticancer and neuroprotective properties.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 98 | In Stock |
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| 10MG | 146 | In Stock |
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| 25MG | 242 | In Stock |
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| 50MG | 358 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameIsolongifolene
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NoteResearch use only, not for human use.
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Brief DescriptionIsolongifolene has antioxidant, anti-inflammatory, anticancer and neuroprotective properties.
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DescriptionIsolongifolene has antioxidant, anti-inflammatory, anticancer and neuroprotective properties. Isolongifolene is a tricyclic sesquiterpene isolated from Murraya koenigii. Isolongifolene attenuates Rotenone-induced oxidative stress, mitochondrial dysfunction and apoptosis through the regulation of P13K/AKT/GSK-3β signaling pathways.
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In VitroIsolongifolene (0-50 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment significantly alleviates Rotenone-induced cytotoxicity in SH-SY5Y cells in a dose-dependent manner.Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone-induced apoptosis in SH-SY5Y cells.Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Furthermore regulation of p-P13K, p-AKT and p-GSK-3β expression by Isolongifolene. Cell Viability Assay Cell Line:SH-SY5Y neuroblastoma cells Concentration:0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM and 50 μM Incubation Time:26 hours Result:Significantly alleviated Rotenone-induced cytotoxicity in SH-SY5Y cells.Apoptosis Analysis Cell Line:SH-SY5Y neuroblastoma cells Concentration:10 μMIncubation Time:26 hours Result:Attenuated Rotenone-induced apoptosis in SH-SY5Y cells.Western Blot AnalysisCell Line:SH-SY5Y neuroblastoma cells Concentration:10 μM Incubation Time:26 hours Result:Attenuated rotenone induced toxicity by down-regulatingBax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Prevented the rotenone-induced decreased phosphorylation of GSK-3β.
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In Vivo——
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Synonyms(-)-Isolongifolene
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number1135-66-6
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Formula Weight204.35
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Molecular FormulaC15H24
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Purity>98% (HPLC)
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SolubilityDMSO:10 mM
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SMILESCC1(C)[C@]23CC[C@](C3)([H])C(C)(C)C2=CCC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Balakrishnan R, et al. Isolongifolene attenuates rotenone-induced mitochondrial dysfunction, oxidative stress and apoptosis. Front Biosci (Schol Ed). 2018 Jan 1;10:248-261.
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