Cart
sales@molnova.com
Home - Products - Others - Other Targets - (Rac)-SHIN2

(Rac)-SHIN2

CAS No. 2204289-53-0

(Rac)-SHIN2( —— )

Catalog No. M36486 CAS No. 2204289-53-0

(Rac)-SHIN2, a serine hydroxymethyltransferase (SHMT) inhibitor, enhances NOTCH1-driven in vivo survival of primary T-ALL in mice and is useful for studying T-cell acute lymphoblastic leukemia (T-ALL).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 128 Get Quote
5MG 186 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    (Rac)-SHIN2
  • Note
    Research use only, not for human use.
  • Brief Description
    (Rac)-SHIN2, a serine hydroxymethyltransferase (SHMT) inhibitor, enhances NOTCH1-driven in vivo survival of primary T-ALL in mice and is useful for studying T-cell acute lymphoblastic leukemia (T-ALL).
  • Description
    (Rac)-SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor having 1,4-dihydropyrano[2,3-c]pyrazole structure. (Rac)-SHIN2 involves in folate or one-carbon metabolism pathways, prevents viral infection. SHMT1 and SHMT2 are the cytosolic and/or mitochondrial isoforms of serine hydroxymethyltransferase, respectively. (Rac)-SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2204289-53-0
  • Formula Weight
    406.48
  • Molecular Formula
    C23H26N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (246.01 mM; Ultrasonic )
  • SMILES
    N#CC1=C(OC=2NN=C(C2C1(C=3C=C(C#CCCCO)C=C(C3)CO)C(C)C)C)N
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mootha Vamsi, et al. Method of treating and preventing viral infection comprising inhibitors of folate or one-carbon metabolism pathways such as serine hydroxymethyltransferase inhibitors: World Intellectual Property Organization, WO2022120195[P]. 2022-06-09.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Ledene

    Ledene is an essential oil produced by viridiflorene synthase. It has been studied as an antimicrobial, antioxidant, antibiofilm and to treat various cancers.

  • Butyl chlorogenate

    Butylchlorogenate is a natural compound isolated from Lonicera japonica, Urceola rosea.

  • 4-(2-Hydroxyethyl)be...

    The leaves of Canarium album.

Sign In Join Free