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Integrin-IN-27
CAS No. 593274-97-6
Integrin-IN-27( MDK-4976 | Integrin Antagonist 27 | MDK4976 | MDK 4976 )
Catalog No. M15199 CAS No. 593274-97-6
A potent integrin αvβ3 antagonist with IC50 of 18 nM; could be conjugated to paclitaxel for selective delivery to alphavbeta3 positive metastatic cancer cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 312 | Get Quote |
|
| 50MG | 1341 | Get Quote |
|
| 100MG | 1791 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameIntegrin-IN-27
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NoteResearch use only, not for human use.
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Brief DescriptionA potent integrin αvβ3 antagonist with IC50 of 18 nM; could be conjugated to paclitaxel for selective delivery to alphavbeta3 positive metastatic cancer cells.
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DescriptionA potent integrin αvβ3 antagonist with IC50 of 18 nM; could be conjugated to paclitaxel for selective delivery to alphavbeta3 positive metastatic cancer cells.
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In Vitro——
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In Vivo——
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SynonymsMDK-4976 | Integrin Antagonist 27 | MDK4976 | MDK 4976
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PathwayCell Cycle/DNA Damage
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TargetIntegrin
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RecptorIntegrin
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number593274-97-6
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Formula Weight444.4394
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Molecular FormulaC24H20N4O5
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(O)C1=CC=CC(N2C(/C=C(C(N3CC(NC4=CC=C(C)C=C4)=O)=O)/NC3=O)=CC=C2)=C1
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Chemical NameBenzoic acid, 3-[2-[[1-[2-[(4-methylphenyl)amino]-2-oxoethyl]-2,5-dioxo-4-imidazolidinylidene]methyl]-1H-pyrrol-1-yl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dayam R, et al. J Med Chem. 2006 Jul 27;49(15):4526-34.
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