RBC8( RBC8 | RBC-8 | RBC 8 )

Catalog No. M17494 CAS No. 361185-42-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

RBC8
Note

Research use only, not for human use.
Brief Description

RBC8 is a specific GTPases RalA/RalB inhibitor by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases RhoA and Ras.
Description

RBC8 is a RalA and RalB GTPase inhibitor (EC50 ~3.5 μM). RBC8 suppresses growth of xenograft tumors in mice. e Ras-like GTPases RalA and RalB are important drivers of tumour growth and metastasis. Chemicals that block Ral function would be valuable as research tools and for cancer therapeutics.
In Vitro

——
In Vivo

——
Synonyms

RBC8 | RBC-8 | RBC 8
Pathway

Cell Cycle/DNA Damage
Target

Integrin
Recptor

GTPases RalA| GTPases RalB
Research Area

Cancer
Indication

——

CAS Number

361185-42-4
Formula Weight

424.45
Molecular Formula

C25H20N4O3
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 40 mg/mL; 94.24 mM
SMILES

COc1ccc(c(c1)C1C(=C(N)Oc2c1c(c1ccc3ccccc3c1)[nH]n2)C#N)OC
Chemical Name

6-Amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)pyrano[2,3-c]pyrazole-5-carbonitrile

1. Yan C, et al. Nature. 2014, 515(7527), 443-447.

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