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Infree

CAS No. 85801-02-1

Infree( —— )

Catalog No. M21168 CAS No. 85801-02-1

Infree is a prodrug of indomethacin. It acts as a nonsteroidal anti-inflammatory drug (NSAID) and disease-modifying anti-rheumatic drug (DMARD).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 45 Get Quote
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Biological Information

  • Product Name
    Infree
  • Note
    Research use only, not for human use.
  • Brief Description
    Infree is a prodrug of indomethacin. It acts as a nonsteroidal anti-inflammatory drug (NSAID) and disease-modifying anti-rheumatic drug (DMARD).
  • Description
    Infree is a prodrug of indomethacin. It acts as a nonsteroidal anti-inflammatory drug (NSAID) and disease-modifying anti-rheumatic drug (DMARD).
  • In Vitro
    Indometacin farnesil (IMF) is a newly synthesized prodrug of indomethacin designed to reduce the occurrence of side-effects by esterification of the carboxyl group of indomethacin with farnesol. This modification is intended to decrease the extraction and subsequent rapid metabolism of the drug by the liver, so that lymphatic absorption would become a major route, and it was also anticipates that hydrolytic enzymes present in plasma and tissues, including inflamed tissue, would release indomethacin effectively from IMF.
  • In Vivo
    Indomethacin farnesil (IMF) can effectively release indomethacin when administered locally. Animal Model:Rats.Dosage:50 nmol a rat paw.Administration:Once.Result:Reduced the level of PGE2 in a dose dependent manner.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    85801-02-1
  • Formula Weight
    562.14
  • Molecular Formula
    C34H40ClNO4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Clc1ccc(cc1)C(=O)n3c2ccc(cc2c(CC(=O)OC\C=C(/C)CC\C=C(/C)CC\C=C(/C)C)c3C)OC
  • Chemical Name
    3711-Trimethyldodeca-2610-trien-1-yl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ono K Hashimoto T Satoh T . Eosinophilic Pustular Folliculitis Clinically Presenting as Orofacial Granuloma: Successful Treatment with Indomethacin But Not Ibuprofen[J]. Acta Dermato Venereologica 2015 95(3):361-362.
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